| Type: | Family | Name: | Phospholipase D, phosphatidylserine synthase type |
| Description: | This entry represents phospholipase D enzymes, such as phosphatidylserine synthase (PSS, or CDP-diacylglycerol--serine O-phosphatidyltransferase; ) and phosphatidylglycerophosphate synthase (PGPS or CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; ). Both these enzymes play essential roles in the regulation of membrane lipids. Membrane lipids are required for multiple roles ranging from messenger roles in signal transduction pathways to a role as substrate for many enzymes. PSS catalyses the convertion of CDP-diacylglycerol and L-serine to CMP and phosphatidylserine. PSS can be found in both eukaryotes and prokaryotes. In mammals, phosphatidylserine is produced through the exchange of L-serine with the base moieties of phosphatidylcholine (PSS 1) and phosphatidylethanolamine (PSS 2) []. In Escherichia coli, the phosphatidylserine synthesised by PSS is rapidly converted to phosphatidylethanolamine []. PGPS catalyses the conversion of CDP-diacylglycerol and glycerol 3-phosphate to CMP and phosphatidylglycerol. | Short Name: | PLipase-D_PtdSer-synthase-type |
