Protein Domain : IPR003286

Type:  Family Name:  RNA-directed DNA polymerase, eukaryota
Description:  Reverse transcriptases occur in a variety of mobile elements, including retrotransposons, retroviruses, group II introns, bacterial msDNAs, hepadnaviruses and caulimoviruses []. The enzyme catalyses RNA-template-directed extension of the 3'-end of DNA strands one deoxynucleotide at a time; it cannot initiate a chain de novo, but requires an RNA or DNA primer, or DNA template.The structure of the unliganded reverse transcriptase (RT) from the Human immunodeficiency virus 1has been solved to 3.2A resolution []. The enzyme is a heterodimer, with domains termed "fingers," "thumb," "palm," and "connection" in both subunits, and a ribonuclease H domain in the larger subunit only []. Ligand binding has been shown to induce changes in the orientation of the thumb. A C-terminal domain common to a group of sequences from the Caenorhabditis eleganssequencing project is revealed by sequence analysis to share a high level of similarity with the RT small subunit. Short Name:  RNA_directed_DNA_poly_euk
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0 Child Features

2 Contains

DB identifier Type Name
IPR005135 Domain Endonuclease/exonuclease/phosphatase
IPR000477 Domain Reverse transcriptase domain

1 Cross References

Identifier
PR01345

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0003723 IPR003286
GO:0003964 IPR003286
GO:0006278 IPR003286

3 Ontology Annotations

GO Term Gene Name
GO:0003723 IPR003286
GO:0003964 IPR003286
GO:0006278 IPR003286

0 Parent Features

3 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Sphfalx0186s0018.1.p PAC:32601016 Sphagnum fallax 190  
Sphfalx0126s0074.1.p PAC:32613639 Sphagnum fallax 416  
Sphfalx0400s0003.1.p PAC:32622175 Sphagnum fallax 394  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            1698615
            7532306