| Type: | Family | Name: | FAD-dependent glycerol-3-phosphate dehydrogenase |
| Description: | FAD-dependent glycerol-3-phosphate dehydrogenase (G3PDH; ) catalyzes the conversion of glycerol-3-phosphate into dihydroxyacetone phosphate:sn-glycerol-3-phosphate + acceptor = glycerone phosphate + reduced acceptor Insulin exposure often stimulates G3PDH activity [, ], and thus is key to reducing the effects of the diseasediabetes. In obese people, where insulin resistance has been demonstrated, the amount of G3PDH has been shown to be correspondingly lower thanthat in normal weight people [].In bacteria [] it is associated with the utilization of glycerol coupled torespiration. In Escherichia coliand Haemophilus influenzae, two isozymes are known: one expressed under anaerobic conditions (gene glpA) and one in aerobic conditions (gene glpD). Ineukaryotes, a mitochondrial form of GPD participates in the glycerol phosphate shuttle in conjunction with an NAD-dependent cytoplasmic GPD () [, ]. This mechanism is responsible forthe preservation of a redox balance [, ]. In this environment, the enzymehas been recorded to increase activity in the presence of calcium [].These enzymes are proteins of about 60 to 70 Kd which contain a probable FAD-binding domain in their N-terminal extremity. The mammalian enzyme differsfrom the bacterial or yeast proteins by having an EF-hand calcium-binding region (see ) in its C-terminal extremity. | Short Name: | G3P_DH_FAD-dep |
| DB identifier | Type | Name |
|---|---|---|
| IPR017752 | Family | Glycerol-3-phosphate dehydrogenase, GlpA subunit |
| GO Term | Gene Name |
|---|---|
| GO:0004368 | IPR000447 |
| GO:0006072 | IPR000447 |
| GO:0055114 | IPR000447 |
| GO:0009331 | IPR000447 |
| GO Term | Gene Name |
|---|---|
| GO:0004368 | IPR000447 |
| GO:0006072 | IPR000447 |
| GO:0055114 | IPR000447 |
| GO:0009331 | IPR000447 |
