Protein Domain : IPR017752

Type:  Family Name:  Glycerol-3-phosphate dehydrogenase, GlpA subunit
Description:  In bacteria, glycerol uptake is mediated by the glycerol diffusion facilitator, an integral membrane protein catalysing the rapid equilibration of concentration gradients of glycerol across the cytoplasmic membrane. Intracellular glycerol is converted to glycerol-3-phosphate that is further metabolised to dihydroxyacetone phosphate (DHAP) by either of two membrane-bound enzymes, depending on the growth conditions.Under aerobic growth conditions, in the presence of glycerol, a glycerol-3-phopshate dehydrogenase (encoded by the glpD gene) is induced, which passes the reducing equivalents to an electron transport chain terminating with oxygen as the electron acceptor. Under anaerobic growth conditions, in the presence of glycerol and fumarate, a different dehydrogenase is induced []. Electrons derived from this reaction are ultimately passed to fumarate as the terminal electron acceptor. The enzyme is composed of three subunits, encoded by the glpABC operon, which are all essential for anaerobic growth on glycerol-3-phosphate []. GlpA and B form the soluble subunit which carries the catalytic site of glycerol-3-phosphate oxidation; while GlpC forms a membrane-bound iron-sulphur subunit, which may act as an anchor for the soluble subunit, and is thought to function in electron transfer from GlpAB to the terminal electron acceptor.This entry represents the GlpA subunit. An archaeal homologue has also recently been characterised [], which appears to be used under aerobic conditions in halophilic archaea. Short Name:  G3P_DH_GlpA_su
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0 Child Features

1 Contains

DB identifier Type Name
IPR007419 Domain BFD-like [2Fe-2S]-binding domain

1 Cross References

Identifier
TIGR03377

0 Found In

6 GO Annotations

GO Term Gene Name
GO:0004368 IPR017752
GO:0010181 IPR017752
GO:0050660 IPR017752
GO:0046174 IPR017752
GO:0055114 IPR017752
GO:0005886 IPR017752

6 Ontology Annotations

GO Term Gene Name
GO:0004368 IPR017752
GO:0010181 IPR017752
GO:0050660 IPR017752
GO:0046174 IPR017752
GO:0055114 IPR017752
GO:0005886 IPR017752

1 Parent Features

DB identifier Type Name
IPR000447 Family FAD-dependent glycerol-3-phosphate dehydrogenase

0 Proteins

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            7576488
            21725010
            6792201