| Type: | Domain | Name: | CD81 antigen, large extracellular loop domain |
| Description: | Human CD81 is a transmembrane protein belonging to the tetraspanin family, whose members are characterised by four hydrophobic transmembrane regions (TM1-4) and two extracellular domains, known as large and small extracellular loops (LEL and SEL, respectively). This entry represents the LEL domain, which is topologically located between TM3 and 4 and contains four invariant Cys residues, two of which define a conserved Cys-Cys-Gly motif []. The key structural features are conserved within the family. | Short Name: | CD81_LEL |
