Protein Domain : IPR005084

Type:  Domain Name:  Carbohydrate binding module family 6
Description:  A carbohydrate-binding module (CBM) is defined as a contiguous amino acid sequence within a carbohydrate-active enzyme with a discreet fold having carbohydrate-binding activity. A few exceptions are CBMs in cellulosomal scaffolding proteins and rare instances of independent putative CBMs. The requirement of CBMs existing as modules within larger enzymes sets this class of carbohydrate-binding protein apart from other non-catalytic sugar binding proteins such as lectins and sugar transport proteins.CBMs were previously classified as cellulose-binding domains (CBDs) based on the initial discovery of several modules that bound cellulose [, ]. However, additional modules in carbohydrate-active enzymes are continually being found that bind carbohydrates other than cellulose yet otherwise meet the CBM criteria, hence the need to reclassify these polypeptides using more inclusive terminology.Previous classification of cellulose-binding domains were based on amino acid similarity. Groupings of CBDs were called "Types" and numbered with roman numerals (e.g. Type I or Type II CBDs). In keeping with the glycoside hydrolase classification, these groupings are now called families and numbered with Arabic numerals. Families 1 to 13 are the same as Types I to XIII. For a detailed review on the structure and binding modes of CBMs see [].This entry represents which was previously known as cellulose-binding domain family VI (CBD VI). CBM6 bind to amorphous cellulose, xylan, mixed beta-(1,3)(1,4)glucan and beta-1,3-glucan[, , ].CBM6 adopts a classic lectin-like beta-jelly roll fold, predominantly consisting of five antiparallel beta-strands on one face and four antiparallel beta-strands on the other face. It contains two potential ligand binding sites, named respectively cleft A and B. These clefts include aromatic residues which are probably involved in the substrate binding. The cleft B is located on the concave surface of one beta-sheet, and the cleft A on one edge of the protein between the loop that connects the inner and outer beta-sheets of the jellyroll fold []. The multiple binding clefts confer the extensive range of specificities displayed by the domain [, , ]. Short Name:  CMB_fam6
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1 Child Features

DB identifier Type Name
IPR006584 Domain Cellulose binding, type IV

0 Contains

2 Cross Referencess

Identifier
PF03422
PS51175

0 Found In

1 GO Annotation

GO Term Gene Name
GO:0030246 IPR005084

1 Ontology Annotations

GO Term Gene Name
GO:0030246 IPR005084

1 Parent Features

DB identifier Type Name
IPR008979 Domain Galactose-binding domain-like

6 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Eucgr.K01691.1.p A0A059A1I2 PAC:32067033 Eucalyptus grandis 685  
Cocit.K1189.3.p PAC:41038045 Corymbia citriodora 691  
Cocit.K1189.2.p PAC:41038044 Corymbia citriodora 691  
Cocit.K1189.1.p PAC:41038043 Corymbia citriodora 691  
Lj1g0003561.2 PAC:44917522 Lotus japonicus 670  
SpUn0939_0010.1 PAC:45088907 Schrenkiella parvula 734  

7 Publications

First Author Title Year Journal Volume Pages PubMed ID
            3338453
            3134347
            15214846
            15010454
            15501830
            15004011
            11673472