GO Term : GO:0019005 SCF ubiquitin ligase complex GO

Namespace:  cellular_component Obsolete:  false
description  A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1).

0 Cross References

1 Data Sets

Name URL
InterPro domain GO annotations  

1 Ontology

Name
GO

2 Ontology Annotations

GO Term Gene Name
GO:0019005 IPR026941
GO:0019005 IPR027046

12 Parents

Identifier Name Description
GO:0043234 protein complex A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical.
GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex.
GO:0031461 cullin-RING ubiquitin ligase complex Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity.
GO:1902494 catalytic complex A protein complex which is capable of catalytic activity.
GO:0044464 cell part Any constituent part of a cell, the basic structural and functional unit of all organisms.
GO:0044424 intracellular part Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
GO:0032991 macromolecular complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.
GO:0005575 cellular_component The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.
GO:0005623 cell The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
GO:1990234 transferase complex A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor).
GO:0019005 SCF ubiquitin ligase complex A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1).

33 Relations

Relationship
Parent Term . Identifier

Child Term . Identifier
is_a GO:0031461 GO:0019005
is_a GO:1902494 GO:0019005
part of GO:0044464 GO:0019005
is_a GO:1990234 GO:0019005
part of GO:0005575 GO:0019005
is_a GO:0044424 GO:0019005
is_a GO:0005575 GO:0019005
part of GO:0005622 GO:0019005
part of GO:0005623 GO:0019005
is_a GO:0032991 GO:0019005
is_a GO:0043234 GO:0019005
is_a GO:0000151 GO:0019005
is_a GO:0044464 GO:0019005
is_a GO:0019005 GO:0043223
is_a GO:0019005 GO:0043223
is_a GO:0019005 GO:0043224
is_a GO:0019005 GO:0043224
is_a GO:0019005 GO:0097660
is_a GO:0019005 GO:0097661
is_a GO:0019005 GO:0097662
is_a GO:0019005 GO:0097663
is_a GO:0019005 GO:0097664
is_a GO:0019005 GO:0097665
is_a GO:0019005 GO:0097666
is_a GO:0019005 GO:0097667
is_a GO:0019005 GO:0097668
is_a GO:0019005 GO:0097669
is_a GO:0019005 GO:0097670
is_a GO:0019005 GO:0097671
is_a GO:0019005 GO:0097672

7 Synonyms

Name Type
Cul1-RING ubiquitin ligase complex synonym
cullin-RING ligase 1 synonym
CDL1 complex synonym
CRL1 complex synonym
Skp1/Cul1/F-box protein complex synonym
SCF complex synonym
SCF complex substrate recognition subunit synonym