GO Term : GO:0008841 dihydrofolate synthase activity GO

Namespace:  molecular_function Obsolete:  false
description  Catalysis of the reaction: ATP + dihydropterate + L-glutamate = ADP + phosphate + dihydrofolate.

0 Cross References

0 Data Sets

1 Ontology

Name
GO

0 Ontology Annotations

57 Parents

Identifier Name Description
GO:0003824 catalytic activity Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.
GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones.
GO:0016874 ligase activity Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate.
GO:0019752 carboxylic acid metabolic process The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-).
GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances.
GO:0009396 folic acid-containing compound biosynthetic process The chemical reactions and pathways resulting in the formation of folic acid and its derivatives.
GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells.
GO:0006807 nitrogen compound metabolic process The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen, including (but not limited to) nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium.
GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents.
GO:0009108 coenzyme biosynthetic process The chemical reactions and pathways resulting in the formation of coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed.
GO:0071704 organic substance metabolic process The chemical reactions and pathways involving an organic substance, any molecular entity containing carbon.
GO:0042558 pteridine-containing compound metabolic process The chemical reactions and pathways involving any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid.
GO:0006082 organic acid metabolic process The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage.
GO:0016881 acid-amino acid ligase activity Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate.
GO:0044238 primary metabolic process The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.
GO:0051188 cofactor biosynthetic process The chemical reactions and pathways resulting in the formation of a cofactor, a substance that is required for the activity of an enzyme or other protein.
GO:0042398 cellular modified amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of compounds derived from amino acids, organic acids containing one or more amino substituents.
GO:0006725 cellular aromatic compound metabolic process The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells.
GO:0016879 ligase activity, forming carbon-nitrogen bonds Catalysis of the joining of two molecules, or two groups within a single molecule, via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate.
GO:0006760 folic acid-containing compound metabolic process The chemical reactions and pathways involving a folic acid-containing compound, i.e. any of a group of heterocyclic compounds based on the pteroic acid skeleton conjugated with one or more L-glutamic acid or L-glutamate units.
GO:0044249 cellular biosynthetic process The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.
GO:0009987 cellular process Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
GO:0051186 cofactor metabolic process The chemical reactions and pathways involving a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate.
GO:0044763 single-organism cellular process Any process that is carried out at the cellular level, occurring within a single organism.
GO:0044699 single-organism process A biological process that involves only one organism.
GO:0008150 biological_process Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.
GO:0003674 molecular_function Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.
GO:0044710 single-organism metabolic process A metabolic process - chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances - which involves a single organism.
GO:0034641 cellular nitrogen compound metabolic process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells.

56 Relations

Relationship
Parent Term . Identifier

Child Term . Identifier
part of GO:0006761 GO:0008841
is_a GO:0016881 GO:0008841
part of GO:1901607 GO:0008841
is_a GO:0016879 GO:0008841
part of GO:0018130 GO:0008841
part of GO:0046483 GO:0008841
is_a GO:0016874 GO:0008841
part of GO:0043650 GO:0008841
part of GO:0008652 GO:0008841
is_a GO:0003674 GO:0008841
part of GO:1901576 GO:0008841
part of GO:0042398 GO:0008841
part of GO:0009987 GO:0008841
part of GO:0044699 GO:0008841
part of GO:0042558 GO:0008841
part of GO:0043648 GO:0008841
part of GO:0043604 GO:0008841
part of GO:0042559 GO:0008841
part of GO:0043603 GO:0008841
part of GO:0009108 GO:0008841
part of GO:0046452 GO:0008841
part of GO:0044271 GO:0008841
part of GO:0051188 GO:0008841
is_a GO:0003824 GO:0008841
part of GO:1901360 GO:0008841
part of GO:1901362 GO:0008841
part of GO:0009058 GO:0008841
part of GO:1901564 GO:0008841
part of GO:1901566 GO:0008841
part of GO:1901605 GO:0008841

12 Synonyms

Name Type
7,8-dihydropteroate:L-glutamate ligase (ADP-forming) synonym
DHFS activity synonym
dihydrofolate synthetase activity synonym
dihydrofolate synthetase-folylpolyglutamate synthetase activity synonym
dihydropteroate:L-glutamate ligase (ADP-forming) activity synonym
FHFS activity synonym
FHFS/FPGS activity synonym
folylpoly-(gamma-glutamate) synthetase-dihydrofolate synthase activity synonym
H(2)-folate synthetase activity synonym
H2-folate synthetase activity synonym
7,8-dihydrofolate synthetase activity synonym
7,8-dihydropteroate:L-glutamate ligase (ADP) activity synonym