GO Term : GO:0008385 IkappaB kinase complex GO

Namespace:  cellular_component Obsolete:  false
description  A trimeric protein complex that phosphorylates inhibitory-kappaB (I-kappaB) proteins. The complex is composed of two kinase subunits (alpha and beta) and a regulatory gamma subunit (also called NEMO). In a resting state, NF-kappaB dimers are bound to inhibitory IKB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.

0 Cross References

0 Data Sets

1 Ontology

Name
GO

0 Ontology Annotations

17 Parents

Identifier Name Description
GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
GO:0043234 protein complex A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical.
GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
GO:0005829 cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
GO:0044445 cytosolic part Any constituent part of cytosol, that part of the cytoplasm that does not contain membranous or particulate subcellular components.
GO:1902494 catalytic complex A protein complex which is capable of catalytic activity.
GO:0044464 cell part Any constituent part of a cell, the basic structural and functional unit of all organisms.
GO:0044444 cytoplasmic part Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
GO:0044424 intracellular part Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
GO:0032991 macromolecular complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.
GO:0005575 cellular_component The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.
GO:0005623 cell The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
GO:1990234 transferase complex A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor).
GO:1902911 protein kinase complex A protein complex which is capable of protein kinase activity.
GO:0061695 transferase complex, transferring phosphorus-containing groups A transferase complex capable of catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor).
GO:1902554 serine/threonine protein kinase complex A protein complex which is capable of protein serine/threonine kinase activity.
GO:0008385 IkappaB kinase complex A trimeric protein complex that phosphorylates inhibitory-kappaB (I-kappaB) proteins. The complex is composed of two kinase subunits (alpha and beta) and a regulatory gamma subunit (also called NEMO). In a resting state, NF-kappaB dimers are bound to inhibitory IKB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.

20 Relations

Relationship
Parent Term . Identifier

Child Term . Identifier
is_a GO:1902554 GO:0008385
is_a GO:0044445 GO:0008385
part of GO:0005829 GO:0008385
part of GO:0044464 GO:0008385
is_a GO:0032991 GO:0008385
part of GO:0044444 GO:0008385
part of GO:0044424 GO:0008385
is_a GO:1902494 GO:0008385
is_a GO:1990234 GO:0008385
is_a GO:0044464 GO:0008385
part of GO:0005575 GO:0008385
part of GO:0005623 GO:0008385
part of GO:0005622 GO:0008385
is_a GO:0061695 GO:0008385
part of GO:0005737 GO:0008385
is_a GO:1902911 GO:0008385
is_a GO:0044444 GO:0008385
is_a GO:0043234 GO:0008385
is_a GO:0005575 GO:0008385
is_a GO:0044424 GO:0008385

3 Synonyms

Name Type
trimeric IKK complex synonym
heterotrimeric IKK complex synonym
IKK complex synonym