GO Term : GO:0004498 calcidiol 1-monooxygenase activity GO

Namespace:  molecular_function Obsolete:  false
description  Catalysis of the reaction: calcidiol + H(+) + NADPH + O(2) = calcitriol + H(2)O + NADP(+).

0 Cross References

0 Data Sets

1 Ontology

Name
GO

0 Ontology Annotations

46 Parents

Identifier Name Description
GO:0003824 catalytic activity Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
GO:0016491 oxidoreductase activity Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
GO:0055114 oxidation-reduction process A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.
GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.
GO:0004497 monooxygenase activity Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water.
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor.
GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones.
GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances.
GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
GO:0006694 steroid biosynthetic process The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification.
GO:0071704 organic substance metabolic process The chemical reactions and pathways involving an organic substance, any molecular entity containing carbon.
GO:0044238 primary metabolic process The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.
GO:0008202 steroid metabolic process The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.
GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor.
GO:0044249 cellular biosynthetic process The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.
GO:0009987 cellular process Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
GO:0006066 alcohol metabolic process The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom.
GO:0044763 single-organism cellular process Any process that is carried out at the cellular level, occurring within a single organism.
GO:0044699 single-organism process A biological process that involves only one organism.
GO:0008150 biological_process Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.
GO:0003674 molecular_function Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.
GO:0044710 single-organism metabolic process A metabolic process - chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances - which involves a single organism.
GO:1901360 organic cyclic compound metabolic process The chemical reactions and pathways involving organic cyclic compound.
GO:0044711 single-organism biosynthetic process A biosynthetic process - chemical reactions and pathways resulting in the formation of substances - involving a single organism.
GO:1901576 organic substance biosynthetic process The chemical reactions and pathways resulting in the formation of an organic substance, any molecular entity containing carbon.
GO:0044281 small molecule metabolic process The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule.
GO:0044283 small molecule biosynthetic process The chemical reactions and pathways resulting in the formation of small molecules, any low molecular weight, monomeric, non-encoded molecule.
GO:1901362 organic cyclic compound biosynthetic process The chemical reactions and pathways resulting in the formation of organic cyclic compound.
GO:0046165 alcohol biosynthetic process The chemical reactions and pathways resulting in the formation of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom.

53 Relations

Relationship
Parent Term . Identifier

Child Term . Identifier
is_a GO:0016709 GO:0004498
part of GO:0036378 GO:0004498
part of GO:1901615 GO:0004498
part of GO:0046173 GO:0004498
part of GO:1901576 GO:0004498
part of GO:0070640 GO:0004498
is_a GO:0003824 GO:0004498
part of GO:0044108 GO:0004498
part of GO:0044107 GO:0004498
is_a GO:0004497 GO:0004498
part of GO:0044249 GO:0004498
part of GO:0042368 GO:0004498
part of GO:0009110 GO:0004498
part of GO:0044763 GO:0004498
part of GO:0019751 GO:0004498
part of GO:1902652 GO:0004498
is_a GO:0016705 GO:0004498
part of GO:0006066 GO:0004498
part of GO:0009058 GO:0004498
part of GO:0008202 GO:0004498
part of GO:0006766 GO:0004498
part of GO:0055114 GO:0004498
part of GO:0046165 GO:0004498
part of GO:0006629 GO:0004498
is_a GO:0016491 GO:0004498
part of GO:0042362 GO:0004498
part of GO:1901362 GO:0004498
part of GO:0044283 GO:0004498
part of GO:1901360 GO:0004498
part of GO:0044281 GO:0004498

12 Synonyms

Name Type
cytochrome P450 CYP27B synonym
1-hydroxylase-25-hydroxyvitamin D3 activity synonym
25-hydroxy vitamin D3 1-alpha-hydroxylase activity synonym
25-hydroxy D3-1alpha-hydroxylase activity synonym
25-hydroxycholecalciferol 1-monooxygenase activity synonym
25-hydroxycholecalciferol 1-hydroxylase activity synonym
25-hydroxycholecalciferol-1-hydroxylase activity synonym
25-hydroxycholecalciferol 1alpha-hydroxylase activity synonym
25-hydroxyvitamin D3 1alpha-hydroxylase activity synonym
25-hydroxyvitamin D-1 alpha hydroxylase activity synonym
calcidiol,NADPH:oxygen oxidoreductase (1-hydroxylating) synonym
25-OHD-1 alpha-hydroxylase activity synonym