GO Term : GO:0003957 NAD(P)+ transhydrogenase (B-specific) activity GO
Namespace:  molecular_function Obsolete:  false
description  Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+, driving the transfer of a solute or solutes from one side of a membrane to the other. In the course of the reaction (left to right) one H atom is transferred from inside the cell to outside. The reaction is B-specific (i.e. the pro-S hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to both NAD+ and NADP+.
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0 Cross References

1 Data Sets

Name URL
InterPro domain GO annotations  

1 Ontology

Name
GO

1 Ontology Annotations

GO Term Gene Name
GO:0003957 IPR022962

39 Parents

Identifier Name Description
GO:0003824 catalytic activity Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
GO:0016491 oxidoreductase activity Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
GO:0055114 oxidation-reduction process A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore.
GO:0055085 transmembrane transport The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other
GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.
GO:0022857 transmembrane transporter activity Enables the transfer of a substance from one side of a membrane to the other.
GO:0005215 transporter activity Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells.
GO:0022891 substrate-specific transmembrane transporter activity Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other.
GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
GO:0034220 ion transmembrane transport A process in which an ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.
GO:0008324 cation transmembrane transporter activity Enables the transfer of cation from one side of the membrane to the other.
GO:0015075 ion transmembrane transporter activity Enables the transfer of an ion from one side of a membrane to the other.
GO:0015078 hydrogen ion transmembrane transporter activity Enables the transfer of hydrogen ions from one side of a membrane to the other.
GO:0016651 oxidoreductase activity, acting on NAD(P)H Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.
GO:0015672 monovalent inorganic cation transport The directed movement of inorganic cations with a valency of one into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Inorganic cations are atoms or small molecules with a positive charge which do not contain carbon in covalent linkage.
GO:0098655 cation transmembrane transport A process in which a cation is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.
GO:0008746 NAD(P)+ transhydrogenase activity Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+.
GO:0009987 cellular process Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
GO:1902600 hydrogen ion transmembrane transport The directed movement of hydrogen ion (proton) across a membrane.
GO:0044763 single-organism cellular process Any process that is carried out at the cellular level, occurring within a single organism.
GO:0044699 single-organism process A biological process that involves only one organism.
GO:0051179 localization Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported to or maintained in a specific location.
GO:1902578 single-organism localization A localization which involves only one organism.
GO:0008150 biological_process Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.
GO:0022890 inorganic cation transmembrane transporter activity Enables the transfer of inorganic cations from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage.
GO:0022892 substrate-specific transporter activity Enables the directed movement of a specific substance or group of related substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells.
GO:0003674 molecular_function Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.

38 Relations

Relationship
Parent Term . Identifier
Child Term . Identifier
is_a GO:0008746 GO:0003957
is_a GO:0015078 GO:0003957
is_a GO:0016491 GO:0003957
is_a GO:0022891 GO:0003957
is_a GO:0022892 GO:0003957
is_a GO:0022890 GO:0003957
part of GO:0015992 GO:0003957
is_a GO:0022857 GO:0003957
part of GO:0015672 GO:0003957
part of GO:0051234 GO:0003957
part of GO:0051179 GO:0003957
is_a GO:0008324 GO:0003957
is_a GO:0003674 GO:0003957
part of GO:0055114 GO:0003957
is_a GO:0005215 GO:0003957
part of GO:0006818 GO:0003957
part of GO:0098655 GO:0003957
part of GO:0006812 GO:0003957
part of GO:0006811 GO:0003957
part of GO:0006810 GO:0003957
is_a GO:0016652 GO:0003957
part of GO:0044710 GO:0003957
part of GO:0044699 GO:0003957
is_a GO:0016651 GO:0003957
part of GO:0008150 GO:0003957
part of GO:1902600 GO:0003957
part of GO:0008152 GO:0003957
is_a GO:0003824 GO:0003957
part of GO:0055085 GO:0003957
is_a GO:0015075 GO:0003957

14 Synonyms

Name Type
NADH transhydrogenase synonym
NADPH-NAD oxidoreductase synonym
NADH-NADP-transhydrogenase synonym
NADPH-NAD transhydrogenase synonym
nicotinamide adenine dinucleotide (phosphate) transhydrogenase synonym
NADPH:NAD+ transhydrogenase synonym
pyridine nucleotide transferase synonym
NAD transhydrogenase synonym
H+-thase synonym
pyridine nucleotide transhydrogenase activity synonym
NAD(P) transhydrogenase (B-specific) activity synonym
NADPH:NAD+ oxidoreductase (B-specific) synonym
non-energy-linked transhydrogenase activity synonym
nicotinamide nucleotide transhydrogenase activity synonym