GO Term : GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway GO
Namespace:  biological_process Obsolete:  false
description  The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent increase in the concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG).
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0 Cross References

1 Data Sets

Name URL
InterPro domain GO annotations  

1 Ontology

Name
GO

3 Ontology Annotations

GO Term Gene Name
GO:0007200 IPR000142
GO:0007200 IPR000356
GO:0007200 IPR000371

34 Parents

Identifier Name Description
GO:0007165 signal transduction The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
GO:0007186 G-protein coupled receptor signaling pathway A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
GO:0035556 intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
GO:0043085 positive regulation of catalytic activity Any process that activates or increases the activity of an enzyme.
GO:0050790 regulation of catalytic activity Any process that modulates the activity of an enzyme.
GO:0051716 cellular response to stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell.
GO:0007154 cell communication Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
GO:0009987 cellular process Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
GO:0044763 single-organism cellular process Any process that is carried out at the cellular level, occurring within a single organism.
GO:0044699 single-organism process A biological process that involves only one organism.
GO:0008150 biological_process Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.
GO:0050896 response to stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism.
GO:0065007 biological regulation Any process that modulates a measurable attribute of any biological process, quality or function.
GO:0050794 regulation of cellular process Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
GO:0050789 regulation of biological process Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
GO:0019222 regulation of metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.
GO:0065009 regulation of molecular function Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding.
GO:0023052 signaling The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered.
GO:0044700 single organism signaling A signaling process occurring within a single organism.
GO:0048518 positive regulation of biological process Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
GO:0044093 positive regulation of molecular function Any process that activates or increases the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding.
GO:0009893 positive regulation of metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent increase in the concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG).
GO:0051336 regulation of hydrolase activity Any process that modulates the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3.
GO:0051345 positive regulation of hydrolase activity Any process that activates or increases the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds.
GO:0048016 inositol phosphate-mediated signaling Any intracellular signal transduction in which the signal is passed on within the cell via an inositol phosphate. Includes production of the inositol phosphate, and downstream effectors that further transmit the signal within the cell. Inositol phosphates are a group of mono- to poly-phosphorylated inositols, and include inositol monophosphate (IP), inositol trisphosphate (IP3), inositol pentakisphosphate (IP5) and inositol hexaphosphate (IP6).
GO:0019932 second-messenger-mediated signaling Any intracellular signal transduction in which the signal is passed on within the cell via a second messenger; a small molecule or ion that can be quickly generated or released from intracellular stores, and can diffuse within the cell. Second-messenger signaling includes production or release of the second messenger, and effectors downstream of the second messenger that further transmit the signal within the cell.
GO:0007202 activation of phospholipase C activity The initiation of the activity of the inactive enzyme phospolipase C as the result of a series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand.
GO:1900274 regulation of phospholipase C activity Any process that modulates the frequency, rate or extent of phospholipase C activity.
GO:0010863 positive regulation of phospholipase C activity Any process that increases the rate of phospholipase C activity.

64 Relations

Relationship
Parent Term . Identifier
Child Term . Identifier
part of GO:0007200 GO:0001596
part of GO:0007200 GO:0001639
has_part GO:0048016 GO:0007200
is_a GO:0007186 GO:0007200
has_part GO:0007202 GO:0007200
part of GO:0050896 GO:0007200
has_part GO:1900274 GO:0007200
has_part GO:0009893 GO:0007200
has_part GO:0010863 GO:0007200
part of GO:0023052 GO:0007200
part of GO:0007154 GO:0007200
has_part GO:0043085 GO:0007200
is_a GO:0050789 GO:0007200
has_part GO:0051336 GO:0007200
has_part GO:0044093 GO:0007200
has_part GO:0050789 GO:0007200
has_part GO:0019932 GO:0007200
part of GO:0044700 GO:0007200
regulates GO:0009987 GO:0007200
is_a GO:0007165 GO:0007200
has_part GO:0007165 GO:0007200
has_part GO:0035556 GO:0007200
is_a GO:0008150 GO:0007200
has_part GO:0065009 GO:0007200
part of GO:0044763 GO:0007200
has_part GO:0010517 GO:0007200
regulates GO:0008150 GO:0007200
has_part GO:0060193 GO:0007200
has_part GO:0065007 GO:0007200
has_part GO:0008150 GO:0007200

8 Synonyms

Name Type
activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger synonym
G protein signaling, coupled to IP3 second messenger (phospholipase C activating) synonym
G protein signalling, coupled to IP3 second messenger (phospholipase C activating) synonym
G-protein coupled receptor signaling pathway coupled to IP3 second messenger synonym
G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) synonym
G-protein signalling, coupled to IP3 second messenger (phospholipase C activating) synonym
phospholipase C-activating dopamine receptor signaling pathway synonym
PLC-activating GPCR signaling pathway synonym