GO Term : GO:0033176 proton-transporting V-type ATPase complex GO

Namespace:  cellular_component Obsolete:  false
description  A proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across a concentration gradient. The resulting transmembrane electrochemical potential of H+ is used to drive a variety of (i) secondary active transport systems via H+-dependent symporters and antiporters and (ii) channel-mediated transport systems. The complex comprises a membrane sector (V0) that carries out proton transport and a cytoplasmic compartment sector (V1) that catalyzes ATP hydrolysis. V-type ATPases are found in the membranes of organelles such as vacuoles, endosomes, and lysosomes, and in the plasma membrane.

0 Cross References

0 Data Sets

1 Ontology

Name
GO

0 Ontology Annotations

8 Parents

Identifier Name Description
GO:0016020 membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
GO:0043234 protein complex A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical.
GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible.
GO:0032991 macromolecular complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.
GO:0005575 cellular_component The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.
GO:0098796 membrane protein complex Any protein complex that is part of a membrane.
GO:0044425 membrane part Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
GO:0033176 proton-transporting V-type ATPase complex A proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across a concentration gradient. The resulting transmembrane electrochemical potential of H+ is used to drive a variety of (i) secondary active transport systems via H+-dependent symporters and antiporters and (ii) channel-mediated transport systems. The complex comprises a membrane sector (V0) that carries out proton transport and a cytoplasmic compartment sector (V1) that catalyzes ATP hydrolysis. V-type ATPases are found in the membranes of organelles such as vacuoles, endosomes, and lysosomes, and in the plasma membrane.

22 Relations

Relationship
Parent Term . Identifier

Child Term . Identifier
part of GO:0033176 GO:0000220
part of GO:0033176 GO:0000221
part of GO:0033176 GO:0000222
part of GO:0033176 GO:0000223
is_a GO:0033176 GO:0016471
is_a GO:0033176 GO:0016471
is_a GO:0016469 GO:0033176
part of GO:0016020 GO:0033176
is_a GO:0032991 GO:0033176
is_a GO:0098796 GO:0033176
part of GO:0005575 GO:0033176
is_a GO:0043234 GO:0033176
is_a GO:0044425 GO:0033176
is_a GO:0005575 GO:0033176
part of GO:0033176 GO:0033179
part of GO:0033176 GO:0033180
is_a GO:0033176 GO:0033181
is_a GO:0033176 GO:0033181
part of GO:0033176 GO:0046610
is_a GO:0033176 GO:0046611
is_a GO:0033176 GO:0046611
part of GO:0033176 GO:0046612

1 Synonyms

Name Type
hydrogen-translocating V-type ATPase complex synonym