| Type: | Family | Name: | Glycoside hydrolase family 56, bee venom hyaluronidase |
| Description: | O-Glycosyl hydrolases () are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families [, ]. This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site.Family 56 () encompasses a group of hyaluronidases () that includes venom hyaluronidases [] and mammalian sperm surface proteins (PH-20).The venom of Apis mellifera(honeybee) contains several biologically-active peptides and two enzymes, one of which is a hyaluronidase []. The amino acid sequence of bee venom hyaluronidase contains 349 amino acids, and includes fourcysteines and a number of potential glycosylation sites []. The sequence shows a high degree of similarity to PH-20, a membrane protein of mammaliansperm involved in sperm-egg adhesion, supporting the view that hyaluronidases play a role in fertilisation []. | Short Name: | Venom_Hyaluronidase |
