3 Ontology Annotations
| GO Term | Gene Name |
|---|---|
| GO:0043565 | IPR003956 |
| GO:0006355 | IPR003956 |
| GO:0005634 | IPR003956 |
| Type: | Conserved_site | Name: | Transcription factor, NFYB/HAP3, conserved site |
| Description: | The CCAAT-binding factor (CBF) is a mammalian transcription factor that binds to a CCAAT motif in the promoters of a wide variety of genes, including type I collagen and albumin. The factor is a heteromericcomplex of A and B subunits, both of which are required for DNA-binding [, ]. The subunits can interact in the absence of DNA-binding, conserved regions in each being important in mediating this interaction.The A subunit can be split into 3 domains on the basis of sequence similarity, a non-conserved N-terminal 'A domain'; a highly-conserved central 'B domain' involved in DNA-binding; and a C-terminal 'C domain', which contains a number of glutamine and acidic residues involved in protein-protein interactions []. The A subunit shows striking similarity to the HAP3 subunit of the yeast CCAAT-binding heterotrimeric transcription factor [, ]. The Kluyveromyces lactisHAP3 protein has been predicted to contain a 4-cysteine zinc finger, which is thought to be present in similar HAP3and CBF subunit A proteins, in which the third cysteine is replaced by a serine []. | Short Name: | Transcrpt_fac_NFYB/HAP3_CS |
| GO Term | Gene Name |
|---|---|
| GO:0043565 | IPR003956 |
| GO:0006355 | IPR003956 |
| GO:0005634 | IPR003956 |
