Protein Domain : IPR015981

Type:  Family Name:  N-acetylglucosamine-6-sulfatase, eukaryotic
Description:  N-acetylglucosamine-6-sulphatase catalyses the hydrolysis of the 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate []. This enzyme is deficient in Sanfilippo Syndrome type IIID []. Mucopolysaccharidosis type III (MPS-III), or Sanfilippo syndrome, is a group of lysosomal storage disorders caused by impaired degradation of heparan sulfate. Short Name:  GlcNAc_6-SO4ase_euk
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0 Child Features

2 Contains

DB identifier Type Name
IPR017849 Domain Alkaline phosphatase-like, alpha/beta/alpha
IPR000917 Domain Sulfatase

1 Cross References

Identifier
PTHR10342:SF212

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0008449 IPR015981
GO:0030203 IPR015981
GO:0005764 IPR015981

3 Ontology Annotations

GO Term Gene Name
GO:0008449 IPR015981
GO:0030203 IPR015981
GO:0005764 IPR015981

1 Parent Features

DB identifier Type Name
IPR012251 Family N-acetylglucosamine-6-sulfatase

0 Proteins

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            3689315
            2500866