Protein Domain : IPR008229

Type:  Family Name:  tRNA nucleotidyltransferase, archaea
Description:  All mature tRNAs contain a terminal CCA sequence essential for function []. CCA-adding enzyme ensures that each tRNA contains a terminal CCA, either by de novo addition or by repair of a damaged end []. CCA-adding enzyme of this group is a class I nucleotidyltransferase unrelated, except at the active site, to class II CCA-adding enzymes () []). Interestingly, despite the fact that class I CCA-adding enzyme combines tRNA cytidylyltransferase () and tRNA adenylyltransferase () activities, it possesses only one active site per monomer []. However, stoichiometric analysis shows formation of a tetramer upon binding of only two tRNA molecules, raising the possibility that two active sites, each responsible for a different nucleotide, form adjacent to each substrate molecule. Short Name:  CCA-adding_arc
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0 Child Features

3 Contains

DB identifier Type Name
IPR011068 Domain Nucleotidyltransferase, class I, C-terminal-like
IPR002934 Domain Polymerase, nucleotidyl transferase domain
IPR015329 Domain tRNA nucleotidyltransferase, substrate binding

3 Cross Referencess

Identifier
PIRSF005335
TIGR03671
MF_01264

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0003723 IPR008229
GO:0004810 IPR008229
GO:0001680 IPR008229

3 Ontology Annotations

GO Term Gene Name
GO:0003723 IPR008229
GO:0004810 IPR008229
GO:0001680 IPR008229

0 Parent Features

0 Proteins

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            11592395
            8809016
            9792681
            11090289