Protein Domain : IPR020625

Type:  Active_site Name:  Schiff base-forming aldolase, active site
Description:  This entry represents an active site found in members of a structural superfamily of Schiff base-forming aldolases that catalyse reactions in different biological pathways. This superfamily includes members such as dihydrodipicolinate synthase (DHDPS), N-acetylneuraminate lyase (NAL) and 2-keto-3-deoxygluconate aldolase (KDG aldolase) []. One of the Escherichia coli proteins containing this site, dapA (), was first identified as dihydrodipicolinate synthase (DHDPS) []. Later, it has been identified as 4-hydroxy-tetrahydrodipicolinate synthases () []. Among the putative DHDPS genes annotated in the A. tumefaciens genome, dapA7 gene product has been shown to possess DHDPS enzyme activity and is allosterically inhibited by lysine []. Short Name:  Schiff_base-form_aldolases_AS

0 Child Features

0 Contains

1 Cross References

Identifier
PS00666

5 Found Ins

DB identifier Type Name
IPR002220 Family DapA-like
IPR005263 Family 4-hydroxy-tetrahydrodipicolinate synthase, DapA
IPR013785 Domain Aldolase-type TIM barrel
IPR005264 Family N-acetylneuraminate lyase
IPR012691 Family 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase variant

2 GO Annotations

GO Term Gene Name
GO:0016829 IPR020625
GO:0008152 IPR020625

2 Ontology Annotations

GO Term Gene Name
GO:0016829 IPR020625
GO:0008152 IPR020625

0 Parent Features

0 Proteins

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            1463470
            24677246
            20503968