3 Ontology Annotations
| GO Term | Gene Name |
|---|---|
| GO:0005432 | IPR004836 |
| GO:0006816 | IPR004836 |
| GO:0016020 | IPR004836 |
| Type: | Family | Name: | Sodium/calcium exchanger protein |
| Description: | Na+/Ca2+exchange proteins are involved in maintaining Ca2+homeostasis in a wide variety of cell types. They are found in both the plasma membraneand intracellular organellar membranes, where they exchange Na+for Ca2+in an electrogenic manner. When located in the plasma membrane, they generallyutilise the transmembrane (TM) Na+concentration gradient in order to extrude Ca2+from cells. Three mammalian isoforms have been cloned to date (NCX1-3), which consist of 920-970 amino acid residues that are predictedto possess 11 or 12 TM domains. Interestingly, they possess a short motif (~30 residues) that is similar to the Na+/K+-ATPase, although its function is unknown [, ].NCX1 has been found to be predominantly expressed in the heart, where it plays an important role in excitation-contraction coupling, but it is alsoabundant in a variety of other tissues []. NCX2 and NCX3 transcripts havebeen detected in the brain and skeletal muscle [, ]. Homologous Na+/Ca2+exchange proteins have also been found in Caenorhabditis elegans, Drosophila melanogasterand Loligo opalescens(California market squid). | Short Name: | Na_Ca_Ex |
| GO Term | Gene Name |
|---|---|
| GO:0005432 | IPR004836 |
| GO:0006816 | IPR004836 |
| GO:0016020 | IPR004836 |
