Protein Domain : IPR002194

Type:  Conserved_site Name:  Chaperonin TCP-1, conserved site
Description:  The TCP-1 protein [, ] (Tailless Complex Polypeptide 1) was first identified in mice where it is especially abundant in testis but present in all cell types. It has since been found and characterised in many other animal species, as well as in yeast, plants and protists. TCP-1 is a highly conserved protein of about 60 kDa (556 to 560 residues) which participates in a hetero-oligomeric 900 kDa double-torus shaped particle [] with 6 to 8 other different subunits. These subunits, the chaperonin containing TCP-1 (CCT) subunit beta, gamma, delta, epsilon, zeta and eta are evolutionary related to TCP-1 itself [, ]. The CCT is known to act as a molecular chaperone for tubulin, actin and probably some other proteins.The CCT subunits are highly related to archaebacterial counterparts:TF55 and TF56 [], a molecular chaperone from Sulfolobus shibatae. TF55 has ATPase activity, is known to bind unfolded polypeptides and forms a oligomeric complex of two stacked nine-membered rings.Thermosome [], from Thermoplasma acidophilum. The thermosome is composed of two subunits (alpha and beta) and also seems to be a chaperone with ATPase activity. It forms an oligomeric complex of eight-membered rings.The TCP-1 family of proteins are weakly, but significantly [], related to the cpn60/groEL chaperonin family (see ). Short Name:  Chaperonin_TCP-1_CS
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0 Child Features

0 Contains

3 Cross Referencess

Identifier
PS00750
PS00751
PS00995

11 Found Ins

DB identifier Type Name
IPR012721 Family T-complex protein 1, theta subunit
IPR012715 Family T-complex protein 1, alpha subunit
IPR012720 Family T-complex protein 1, eta subunit
IPR012722 Family T-complex protein 1, zeta subunit
IPR012718 Family T-complex protein 1, epsilon subunit
IPR017998 Family Chaperone tailless complex polypeptide 1 (TCP-1)
IPR012719 Family T-complex protein 1, gamma subunit
IPR002423 Family Chaperonin Cpn60/TCP-1 family
IPR012716 Family T-complex protein 1, beta subunit
IPR012717 Family T-complex protein 1, delta subunit
IPR012714 Family Thermosome, archaeal

3 GO Annotations

GO Term Gene Name
GO:0005524 IPR002194
GO:0051082 IPR002194
GO:0006457 IPR002194

3 Ontology Annotations

GO Term Gene Name
GO:0005524 IPR002194
GO:0051082 IPR002194
GO:0006457 IPR002194

0 Parent Features

0 Proteins

8 Publications

First Author Title Year Journal Volume Pages PubMed ID
            7794526
            15335898
            7953530
            1836250
            1352040
            1352857
            1630492
            7846767