| Type: | Family | Name: | Protein phosphatase 1 regulatory subunit 12A/B, chordates |
| Description: | This group represents a protein phosphatase 1 regulatory subunits 12A/B (also known as MYPT1/MYPT2) from vertebrates. They are key regulators of protein phosphatase 1C (PPP1C). They modulates Ca(2+)-dependent phosphorylation of myosin light chain by myosin light chain kinase, which is essential for smooth muscle contraction [, ]. MYPT2 have similar features as MYPT1, such as: a specific interaction with the catalytic subunit of type 1 phosphatase, delta isoform (PP1cdelta); interaction of MYPT2 with the small heart-specific MP subunit; interaction of the C-terminal region of MYPT2 with the active form of RhoA; phosphorylation by Rho-kinase at an inhibitory site, Thr646 and thiophosphorylation at Thr646 inhibited activity of the MYPT2-PP1cdelta complex []. | Short Name: | MYPT1/MYPT2_chordates |
