Protein Domain : IPR017094

Type:  Family Name:  Biliverdin reductase A
Description:  This entry represents biliverdin reductase A enzymes (), reduces biliverdin (the product of haem oxygenases HO-1 and HO-2 activity) to the antioxidant bilirubin. It works by catalysing the reduction of the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor. This reaction is involved in the protohaem degradation pathway as part of porphyrin metabolism. Some enzymes are thought to use zinc as a cofactor. Human biliverdin reductase may also functions as a kinase and as a transcription factor in the MAPK (mitogen-activated protein kinase) signalling cascade []. Short Name:  Biliverdin_Rdtase_A
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0 Child Features

3 Contains

DB identifier Type Name
IPR016040 Domain NAD(P)-binding domain
IPR000683 Domain Oxidoreductase, N-terminal
IPR015249 Domain Biliverdin reductase, catalytic

1 Cross References

Identifier
PIRSF037032

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0004074 IPR017094
GO:0042167 IPR017094
GO:0055114 IPR017094
GO:0005737 IPR017094

4 Ontology Annotations

GO Term Gene Name
GO:0004074 IPR017094
GO:0042167 IPR017094
GO:0055114 IPR017094
GO:0005737 IPR017094

0 Parent Features

0 Proteins

1 Publications

First Author Title Year Journal Volume Pages PubMed ID
            18412543