GO Term : GO:0006621 protein retention in ER lumen GO

Namespace:  biological_process Obsolete:  false
description  The retention in the endoplasmic reticulum (ER) lumen of soluble resident proteins. Sorting receptors retrieve proteins with ER localization signals, such as KDEL and HDEL sequences or some transmembrane domains, that have escaped to the cis-Golgi network and return them to the ER. Abnormally folded proteins and unassembled subunits are also selectively retained in the ER.

0 Cross References

1 Data Sets

Name URL
InterPro domain GO annotations  

1 Ontology

Name
GO

10158 Ontology Annotations

Class GO Term Gene Name Db
OntologyAnnotation GO:0006621 115638 GO
GOAnnotation GO:0006621 115638  
GOAnnotation GO:0006621 143476  
OntologyAnnotation GO:0006621 143476 GO
OntologyAnnotation GO:0006621 75833 GO
GOAnnotation GO:0006621 75833  
OntologyAnnotation GO:0006621 162537 GO
GOAnnotation GO:0006621 162537  
OntologyAnnotation GO:0006621 evm.model.supercontig_26.41 GO
GOAnnotation GO:0006621 evm.TU.supercontig_26.41  
GOAnnotation GO:0006621 evm.TU.supercontig_37.199  
OntologyAnnotation GO:0006621 evm.model.supercontig_37.199 GO
OntologyAnnotation GO:0006621 evm.model.supercontig_428.5 GO
GOAnnotation GO:0006621 evm.TU.supercontig_428.5  
GOAnnotation GO:0006621 evm.TU.supercontig_7.117  
OntologyAnnotation GO:0006621 evm.model.supercontig_7.117 GO
GOAnnotation GO:0006621 evm.TU.supercontig_8.138  
OntologyAnnotation GO:0006621 evm.model.supercontig_8.138 GO
OntologyAnnotation GO:0006621 29711.m000331 GO
GOAnnotation GO:0006621 29711.t000013  
OntologyAnnotation GO:0006621 29904.m002932 GO
GOAnnotation GO:0006621 29904.t000046  
OntologyAnnotation GO:0006621 30026.m001475 GO
GOAnnotation GO:0006621 30026.t000039  
GOAnnotation GO:0006621 30073.t000051  
OntologyAnnotation GO:0006621 30073.m002241 GO
OntologyAnnotation GO:0006621 30120.m000373 GO
GOAnnotation GO:0006621 30120.t000024  
GOAnnotation GO:0006621 30170.t000595  
OntologyAnnotation GO:0006621 30170.m014183 GO

36 Parents

Identifier Name Description
GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
GO:0043231 intracellular membrane-bounded organelle Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
GO:0006621 protein retention in ER lumen The retention in the endoplasmic reticulum (ER) lumen of soluble resident proteins. Sorting receptors retrieve proteins with ER localization signals, such as KDEL and HDEL sequences or some transmembrane domains, that have escaped to the cis-Golgi network and return them to the ER. Abnormally folded proteins and unassembled subunits are also selectively retained in the ER.
GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
GO:0009987 cellular process Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
GO:0008104 protein localization Any process in which a protein is transported to, or maintained in, a specific location.
GO:0044763 single-organism cellular process Any process that is carried out at the cellular level, occurring within a single organism.
GO:0044699 single-organism process A biological process that involves only one organism.
GO:0051641 cellular localization A localization process that takes place at the cellular level; as a result of a cellular localization process, a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within or in the membrane of a cell.
GO:0051179 localization Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported to or maintained in a specific location.
GO:1902578 single-organism localization A localization which involves only one organism.
GO:0008150 biological_process Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.
GO:0044464 cell part Any constituent part of a cell, the basic structural and functional unit of all organisms.
GO:0044444 cytoplasmic part Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
GO:0044424 intracellular part Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
GO:0005575 cellular_component The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.
GO:0005623 cell The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
GO:0065007 biological regulation Any process that modulates a measurable attribute of any biological process, quality or function.
GO:0034613 cellular protein localization Any process in which a protein is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell.
GO:0070727 cellular macromolecule localization Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell.
GO:0033036 macromolecule localization Any process in which a macromolecule is transported to, or maintained in, a specific location.
GO:0033365 protein localization to organelle A process in which a protein is transported to, or maintained in, a location within an organelle.
GO:0043227 membrane-bounded organelle Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
GO:0043226 organelle Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane.
GO:0043229 intracellular organelle Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
GO:0012505 endomembrane system A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles.
GO:0065008 regulation of biological quality Any process that modulates a qualitative or quantitative trait of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc.
GO:0070972 protein localization to endoplasmic reticulum A process in which a protein is transported to, or maintained in, a location within the endoplasmic reticulum.
GO:0035437 maintenance of protein localization in endoplasmic reticulum Any process in which a protein is maintained in the endoplasmic reticulum and prevented from moving elsewhere. These include sequestration within the endoplasmic reticulum, protein stabilization to prevent transport elsewhere and the active retrieval of proteins that escape the endoplasmic reticulum.

37 Relations

Relationship
Parent Term . Identifier

Child Term . Identifier
is_a GO:0035437 GO:0006621
part of GO:0051179 GO:0006621
is_a GO:0008150 GO:0006621
is_a GO:0065007 GO:0006621
is_a GO:0065008 GO:0006621
occurs in GO:0005575 GO:0006621
part of GO:0070972 GO:0006621
occurs in GO:0043227 GO:0006621
occurs in GO:0043229 GO:0006621
part of GO:0033365 GO:0006621
is_a GO:0051220 GO:0006621
occurs in GO:0005737 GO:0006621
is_a GO:0072595 GO:0006621
part of GO:0034613 GO:0006621
part of GO:0008150 GO:0006621
occurs in GO:0043231 GO:0006621
occurs in GO:0044464 GO:0006621
occurs in GO:0044444 GO:0006621
occurs in GO:0044424 GO:0006621
is_a GO:1902578 GO:0006621
is_a GO:0044763 GO:0006621
is_a GO:0032507 GO:0006621
part of GO:0051641 GO:0006621
occurs in GO:0005783 GO:0006621
is_a GO:0044699 GO:0006621
occurs in GO:0005622 GO:0006621
occurs in GO:0005623 GO:0006621
part of GO:0033036 GO:0006621
is_a GO:0051651 GO:0006621
part of GO:0070727 GO:0006621

1 Synonyms

Name Type
maintenance of protein location in ER lumen synonym