Protein Domain : IPR001665

Type:  Domain Name:  Norovirus peptidase C37
Description:  Noroviruses (NVs, formerly "Norwalk-like viruses"), which belong to the Caliciviridae, are the major causative agents of nonbacterial acutegastroenteritis in humans. The NV genome, which consists of positive-sense, single-stranded RNA, contains three open reading frames (ORFs). The first ORFproduces a polyprotein that is processed by the viral 3C-like protease into six nonstructural proteins. The six NV ORF1 nonstructural proteins arehomologous to picornaviral nonstructural proteins and are named accordingly: N-terminal protein, 2C-like nucleoside triphosphatase, 3A-like protein, 3B VPg(genome-linked viral protein), 3C-like protease, and a 3D RNA- dependent RNA polymerase. NV 3C-like proteases are the key enzymes for ORF1 polyproteinprocessing and also cleave the poly(A)-binding protein, causing cellular translation inhibition. NV 3C-like proteases belong to the chymotrypsin-like proteasefamily, in that they appear to have chymotrypsin-like folds. Whether the 3C-like protease domain has a catalytic dyad of composed of histidine and cysteine ortryad of histidine, glutamate and cysteine remains controversial [, ]. The NV3C-like protease domain forms MEROPS peptidase family C37.The NV 3C-like protease domain adopts a serine protease-like fold that consists of two beta-barrels separated by a cleft within which lie the active site catalyticresidues. The N-terminal beta barrel has two alpha-helices and seven beta-strands. The beta-strands form a twisted antiparallel beta-sheet resembling an incomplete beta-barrel. The core of the incomplete beta- barrel contains hydrophobic residues. The active site histidine residue isfound in the N-terminal beta-barrel, as well as the glutamate. The C-terminal six-stranded antiparallel beta-barrel contains the active site cysteine. Thecatalytic site formed is situated deep within a cleft between the N- and C- terminal beta-barrels [, ]. Short Name:  Norovirus_pept_C37
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0 Child Features

0 Contains

3 Cross Referencess

Identifier
PF05416
PR00917
PS51537

0 Found In

2 GO Annotations

GO Term Gene Name
GO:0004197 IPR001665
GO:0006508 IPR001665

2 Ontology Annotations

GO Term Gene Name
GO:0004197 IPR001665
GO:0006508 IPR001665

1 Parent Features

DB identifier Type Name
IPR009003 Domain Peptidase S1, PA clan

1 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Brame.01UG277700.1.p PAC:45219341 Brachypodium mexicanum 301  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            16641296
            16227288