Type: | Family | Name: | Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66 |
Description: | NO66 specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code. It acts as a regulator of osteoblast differentiation and may also play a role in ribosome biogenesis and in the replication or remodeling of certain heterochromatic region [, ]. MYC-induced nuclear antigen is involved in cellular proliferation [, , ]. It may be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles []. | Short Name: | NO66 |