Protein Domain : IPR000951

Type:  Family Name:  Phthalate dioxygenase reductase
Description:  Flavoprotein pyridine nucleotide cytochrome reductases [] (FPNCR) catalyse the interchange of reducing equivalents between one-electron carriers and the two-electron-carrying nicotinamide dinucleotides. The enzymes include ferredoxin:NADP+ reductases (FNR) []; plant and fungal NAD(P)H:nitrate reductases []; NADH:cytochrome B5 reductases; NADPH:P450 reductases; NADPH:sulphite reductases; nitric oxide synthases; phthalate dioxygenase reductase []; and various other flavoproteins. Phthalate dioxygenase reductase (PDR) is a member of a family of FPNCR/[2Fe-2S]ferredoxin fusion proteins, found in flavobacteria, that participate in oxidative metabolism of a variety of substrates. Other family members are vanillate demethylase reductase []; phenoxybenzoate dioxygenase; and pentachlorophenol 4-monooxygenase. All of contain a [2Fe-2S]ferredoxin domain fused to the C terminus of an FPNCR domain. The direction of electron flow is from flavin to the [2Fe-2S] centre. By contrast with most FPNCRs, PDR binds FMN instead of FAD. The 3D-structure of PDR has been solved []. The overall fold of the FPNCR module is similar to that of ferredoxin:NADP+ reductase []; the FMN-binding domain (N-terminal) has the topology of an anti-parallel beta-barrel; and the NAD(P)-binding domain (C-terminal) has the topology of a classical pyridine dinucleotide-binding fold, a central parallel beta-sheet flanked by 2 helices on each side. Short Name:  Ph_dOase_redase
Paste the following link

0 Child Features

7 Contains

DB identifier Type Name
IPR012675 Domain Beta-grasp domain
IPR001041 Domain 2Fe-2S ferredoxin-type iron-sulfur binding domain
IPR017938 Domain Riboflavin synthase-like beta-barrel
IPR001433 Domain Oxidoreductase FAD/NAD(P)-binding
IPR017927 Domain Ferredoxin reductase-type FAD-binding domain
IPR008333 Domain Oxidoreductase, FAD-binding domain
IPR006058 Binding_site 2Fe-2S ferredoxin, iron-sulphur binding site

1 Cross References

Identifier
PR00409

0 Found In

1 GO Annotation

GO Term Gene Name
GO:0016491 IPR000951

1 Ontology Annotations

GO Term Gene Name
GO:0016491 IPR000951

0 Parent Features

3 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
33527.m000029 B9TJ52 PAC:16825888 Ricinus communis 267  
49756.m000015 B9TM69 PAC:16828202 Ricinus communis 305  
Pahal.J02029.1 PAC:32488717 Panicum hallii 401  

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            3170489
            8027025
            1748631
            1280857