Protein Domain : IPR005888

Type:  Family Name:  dTDP-glucose 4,6-dehydratase
Description:  The conversion of dTDP-glucose into dTDP-4-keto-6-deoxyglucose by Escherichia colidTDP-glucose 4,6-dehydratase) takes place in the active site in three steps: dehydrogenation to dTDP-4-ketoglucose, dehydration to dTDP-4-ketoglucose-5,6-ene, and rereduction of C6 to the methyl group. The 4,6-dehydratase makes use of tightly bound NAD+as the coenzyme for transiently oxidizing the substrate, activating it for the dehydration step []. This and other 4,6-dehydratases catalyze the first committed step in all 6-deoxysugar biosynthetic pathways described to date. Numerous6-deoxysugars are used in bacterial lipopolysaccharide production as well as in the biosynthesis of a diverse array of secondary metabolites. Short Name:  dTDP_Gluc_deHydtase
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1 Child Features

DB identifier Type Name
IPR026390 Family NAD dependent epimerase/dehydratase, LLPSF_EDH_00030 family

1 Contains

DB identifier Type Name
IPR016040 Domain NAD(P)-binding domain

2 Cross Referencess

Identifier
PTHR10366:SF41
TIGR01181

0 Found In

2 GO Annotations

GO Term Gene Name
GO:0008460 IPR005888
GO:0009225 IPR005888

2 Ontology Annotations

GO Term Gene Name
GO:0008460 IPR005888
GO:0009225 IPR005888

0 Parent Features

306 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
29848.m004471 B9RNP1 PAC:16811128 Ricinus communis 369  
AT1G53500.1 Q9LPG6 PAC:19654504 Arabidopsis thaliana 667  
AT1G78570.1 Q9SYM5 PAC:19652089 Arabidopsis thaliana 669  
Thhalv10011290m V4JX99 PAC:20184045 Eutrema salsugineum 667  
Thhalv10018232m V4JPY4 PAC:20191640 Eutrema salsugineum 669  
Potri.001G383500.1 U5GSR1 PAC:27042015 Populus trichocarpa 670  
Potri.001G383500.2 PAC:27042016 Populus trichocarpa 655  
Potri.006G272700.1 B9N673 PAC:27004715 Populus trichocarpa 660  
Potri.011G103700.1 A0A2K1YI85 PAC:27002378 Populus trichocarpa 670  
Potri.011G103700.2 A0A2K1YI85 PAC:27002377 Populus trichocarpa 670  
Gorai.002G046200.2 A0A0D2R0N9 PAC:26793274 Gossypium raimondii 667  
Gorai.002G046200.1 A0A0D2R0N9 PAC:26793275 Gossypium raimondii 667  
Gorai.002G046200.3 A0A0D2R0N9 PAC:26793276 Gossypium raimondii 667  
Gorai.009G362500.2 A0A0D2SED5 PAC:26763062 Gossypium raimondii 535  
70789 C1NAB9 PAC:27343779 Micromonas pusilla CCMP1545 777  
93395 C1DYM1 PAC:27396330 Micromonas sp RCC299 759  
Migut.H02027.1.p A0A022QFB8 PAC:28953015 Mimulus guttatus 669  
Araha.19449s0006.1.p PAC:28862332 Arabidopsis halleri 668  
Cagra.1361s0003.1.p PAC:28915571 Capsella grandiflora 669  
Glyma.08G148100.1.p I1KTG8 PAC:30538270 Glycine max 668  
Glyma.12G234300.1.p I1LVA7 PAC:30547203 Glycine max 669  
Glyma.12G234300.2.p I1LVA7 PAC:30547204 Glycine max 669  
Glyma.15G210300.1.p I1MI49 PAC:30497613 Glycine max 668  
Glyma.15G210300.3.p I1MI49 PAC:30497612 Glycine max 668  
Glyma.15G210300.2.p I1MI49 PAC:30497611 Glycine max 668  
Brara.A03173.1.p A0A398AYC6 PAC:30640213 Brassica rapa FPsc 663  
Brara.E01485.1.p A0A397Z9T5 PAC:30624230 Brassica rapa FPsc 668  
Bostr.0124s0139.1.p PAC:30656333 Boechera stricta 667  
Bostr.20129s0290.1.p PAC:30673979 Boechera stricta 669  
Medtr0034s0060.1 A0A072TI08 PAC:31084542 Medicago truncatula 798  

1 Publications

First Author Title Year Journal Volume Pages PubMed ID
            11851427