Type: | Domain | Name: | Transcription-repair-coupling factor, C-terminal domain |
Description: | This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli. A lesion in the template strand blocks the RNA polymerase complex (RNAP). The RNAP-DNA-RNA complex is specifically recognised by the transcription-repair-coupling factor (TRCF) which releases RNAP and the truncated transcript.The C-terminal region of TRCF have been shown to be necessary for RNAP displacement [, ]. | Short Name: | TRCF_C |