Protein Domain : IPR004576

Type:  Family Name:  Transcription-repair coupling factor
Description:  The bacterial transcription-repair coupling factor (Mfd) binds to stalled transcription elongation complexes in vitro and catalyses their dissociation from template DNA in an ATP-dependent manner []. A lesion in the template strand blocks the RNA polymerase complex (RNAP). The RNAP-DNA-RNA complex is specifically recognised by Mdf, which releases RNAP and the truncated transcript. Mfd displaces RNAP at the lesion site by pushing the polymerase forward [], allowing the lesion to be accessed by repair proteins []. Mfd contains superfamily II helicase motifs which are essential for the RNAP displacement activity of Mfd [], but does not possess conventional strand-separating helicase activity []. Short Name:  Mfd
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0 Child Features

4 Contains

DB identifier Type Name
IPR001650 Domain Helicase, C-terminal
IPR011545 Domain DEAD/DEAH box helicase domain
IPR003711 Domain CarD-like/TRCF domain
IPR005118 Domain Transcription-repair-coupling factor, C-terminal domain

2 Cross Referencess

Identifier
TIGR00580
MF_00969

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0003684 IPR004576
GO:0005524 IPR004576
GO:0006281 IPR004576

3 Ontology Annotations

GO Term Gene Name
GO:0003684 IPR004576
GO:0005524 IPR004576
GO:0006281 IPR004576

0 Parent Features

4 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Araha.11756s0032.1.p PAC:28856510 Arabidopsis halleri 790  
Brdisv1BdTR11G1045837m.p PAC:34644204 Brachypodium distachyon BdTR11g 828  
Brdisv1BdTR11A1040625m.p PAC:35688158 Brachypodium distachyon BdTR11a 1151  
Zosma07g00140 PAC:50102172 Zostera marina 1153  

5 Publications

First Author Title Year Journal Volume Pages PubMed ID
            22904071
            7876262
            21145481
            12086674
            15063847