Protein Domain : IPR019888

Type:  Family Name:  Transcription regulator AsnC-type
Description:  The many bacterial transcription regulation proteins which bind DNA through a 'helix-turn-helix' motif can be classified into subfamilies on the basis ofsequence similarities. One such family is the AsnC/Lrp subfamily []. The Lrp family of transcriptional regulators appears to be widely distributed among bacteria andarchaea, as an important regulatory system of the amino acid metabolism and related processes []. Members of the Lrp family are small DNA-binding proteins with molecular masses of around 15 kDa. Target promoters often contain anumber of binding sites that typically lack obvious inverted repeat elements, and to which binding is usually co-operative. LrpA from Pyrococcus furiosusis the first Lrp-like protein to date of which a three-dimensional structure has been solved. In the crystal structure LrpA forms an octamer consistingof four dimers. The structure revealed that the N-terminal part of the protein consists of a helix-turn-helix (HTH) domain, a fold generally involved in DNA binding.The C terminus of Lrp-like proteins has a beta-fold, where the two alpha-helices are located at one side of the four-stranded antiparallel beta-sheet. LrpA forms a homodimer mainly through interactions between the beta-strands of this C-terminaldomain, and an octamer through further interactions between the second alpha-helix and fourth beta-strand of the motif. Hence, the C-terminal domain of Lrp-like proteins appears tobe involved in ligand-response and activation []. Short Name:  Tscrpt_reg_AsnC-typ
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0 Child Features

5 Contains

DB identifier Type Name
IPR011991 Domain Winged helix-turn-helix DNA-binding domain
IPR011008 Domain Dimeric alpha-beta barrel
IPR019887 Domain Transcription regulator AsnC-type, C-terminal
IPR000485 Domain AsnC-type HTH domain
IPR019885 Conserved_site Transcription regulator HTH, AsnC-type, conserved site

1 Cross References

Identifier
SM00344

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0003700 IPR019888
GO:0043565 IPR019888
GO:0006355 IPR019888
GO:0005622 IPR019888

4 Ontology Annotations

GO Term Gene Name
GO:0003700 IPR019888
GO:0043565 IPR019888
GO:0006355 IPR019888
GO:0005622 IPR019888

0 Parent Features

4 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
30316.m000024 B9TJJ9 PAC:16824337 Ricinus communis 172  
33925.m000029 B9TF53 PAC:16826034 Ricinus communis 160  
27712.m000038 B9TBH7 PAC:16798993 Ricinus communis 152  
Pp3s32_30V3.1.p PAC:32948416 Physcomitrium patens 2661  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            7770911
            12675791