Protein Domain : IPR013014

Type:  Domain Name:  Phosphotransferase system, EIIC component, type 2
Description:  The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS) [, ] is a major carbohydrate transport system in bacteria. The PTS catalyses the phosphorylation of incoming sugar substrates and coupled with translocation across the cell membrane, makes the PTS a link between the uptake and metabolism of sugars.The general mechanism of the PTS is the following: a phosphoryl group from phosphoenolpyruvate (PEP) is transferred via a signal transduction pathway, to enzyme I (EI) which in turn transfers it to a phosphoryl carrier, the histidine protein (HPr). Phospho-HPr then transfers the phosphoryl group to a sugar-specific permease, a membrane-bound complex known as enzyme 2 (EII), which transports the sugar to the cell. EII consists of at least three structurally distinct domains IIA, IIB and IIC []. These can either be fused together in a single polypeptide chain or exist as two or three interactive chains, formerly called enzymes II (EII) and III (EIII). The first domain (IIA or EIIA) carries the first permease-specific phosphorylation site, a histidine which is phosphorylated by phospho-HPr. The second domain (IIB or EIIB) is phosphorylated by phospho-IIA on a cysteinyl or histidyl residue, depending on the sugar transported. Finally, the phosphoryl group is transferred from the IIB domain to the sugar substrate concomitantly with the sugar uptake processed by the IIC domain. This third domain (IIC or EIIC) forms the translocation channel and the specific substrate-binding site. An additional transmembrane domain IID, homologous to IIC, can be found in some PTSs, e.g. for mannose [, , , ]. According to sequence analyses [, , ], the PTS EIIC domain can be divided in five groups:The PTS EIIC type 1 domain is found in the Glucose class of PTS and has an average length of about 80 amino acids. The PTS EIIC type 2 domain is found in the Mannitol class of PTS and has an average length of about 90 amino acids.The PTS EIIC type 3 domain is found in the Lactose class of PTS and has an average length of about 100 amino acids. The PTS EIIC type 4 domain is found in the Mannose class of PTS and has an average length of about 160 amino acids. The PTS EIIC type 5 domain is found in the Sorbitol class of PTS and has an average length of about 190 amino acids. This entry represents the type 2 domain. Short Name:  PTS_EIIC_2
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2 Child Features

DB identifier Type Name
IPR006327 Domain Phosphotransferase system, fructose IIC component
IPR004718 Domain Phosphotransferase system, mannitol-specific enzyme IIC

0 Contains

1 Cross References

Identifier
PS51104

2 Found Ins

DB identifier Type Name
IPR013853 Family Galactitol permease IIC component
IPR004703 Family Phosphotransferase system, sugar-specific permease component

0 GO Annotation

0 Ontology Annotations

1 Parent Features

DB identifier Type Name
IPR003352 Domain Phosphotransferase system, EIIC

6 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Araha.11756s0242.1.p PAC:28856383 Arabidopsis halleri 564  
Pp3s30_10V3.1.p PAC:32948448 Physcomitrium patens 443  
Brdisv1pangenome1006693m.p PAC:33621128 Brachypodium distachyon Pangenome 640  
Brdisv1pangenome1007266m.p PAC:33641287 Brachypodium distachyon Pangenome 970  
Brdisv1BdTR11A1041495m.p PAC:35695100 Brachypodium distachyon BdTR11a 640  
Brdisv1BdTR11A1042114m.p PAC:35688106 Brachypodium distachyon BdTR11a 970  

5 Publications

First Author Title Year Journal Volume Pages PubMed ID
            2197982
            8246840
            1537788
            7815935
            11361063