Protein Domain : IPR004476

Type:  Family Name:  Ribonuclease II/ribonuclease R
Description:  This family is defined to identify a pair of paralogous 3'->5' exoribonucleases in Escherichia coli, plus the set of proteins apparently orthologous to one or the other in other eubacteria. VacB was characterised originally as required for the expression of virulence genes, but is now recognised as the exoribonuclease RNase R (Rnr). Its paralog in Escherichia coliand Haemophilus influenzaeis designated exoribonuclease II (Rnb) []. Both are involved in the degradation of mRNA, and consequently have strong pleiotropic effects that may be difficult to disentangle. Both these proteins share domain-level similarity (RNB, S1) with a considerable number of other proteins, and full-length similarity scoring below the trusted cut-off to proteins associated with various phenotypes but uncertain biochemistry; it may be that these latter proteins are also 3' exoribonucleases. Short Name:  RNase_II/RNase_R
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2 Child Features

DB identifier Type Name
IPR011804 Family Ribonuclease II
IPR011805 Family Ribonuclease R

3 Contains

DB identifier Type Name
IPR003029 Domain S1 domain
IPR011129 Domain Cold shock protein
IPR013223 Domain Ribonuclease B, N-terminal OB domain

1 Cross References

Identifier
TIGR00358

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0003723 IPR004476
GO:0004540 IPR004476
GO:0016070 IPR004476

3 Ontology Annotations

GO Term Gene Name
GO:0003723 IPR004476
GO:0004540 IPR004476
GO:0016070 IPR004476

0 Parent Features

2 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Araha.11756s0009.1.p PAC:28856545 Arabidopsis halleri 645  
Araha.11756s0235.1.p PAC:28856294 Arabidopsis halleri 724  

1 Publications

First Author Title Year Journal Volume Pages PubMed ID
            11948193