Protein Domain : IPR030553

Type:  Family Name:  Torsin-like protein
Description:  Torsin-like proteins are torsin-1A homologues, which belong to the torsin family. Caenorhabditis elegans torsin-like protein, also known as ooc-5, may serve as a redox-regulated sensor []. Similar to human Torsin-1A, ooc-5 is also located in the endoplasmic reticulum (ER)/nuclear envelope (NE) []. Loss of ooc-5 disrupts nuclear rotation during early embryogenesis []. This entry also includes a torsin-like protein from Drosophila (Dtorsin), also found in the NE and ER, which plays a role in dopamine metabolism []. Downregulation of dtorsin results in increased age-related retinal degeneration [].Torsin family members are membrane-associated ATPases belonging to the AAA+ (ATPase associated with a variety of cellular activities) superfamily of ATPases. The AAA+ ATPases typically form oligomeric rings obtaining energy from ATP hydrolysis and acting as chaperone-like modules [, ]. However, torsins lack conserved catalytic residues typically found in related ATPases and do not display ATPase activity unless they are engaged by their regulatory cofactors lamina-associated polypeptide 1 (LAP1) or luminal domain-like LAP1 (LULL1) [], which are type II transmembrane proteins located in the nuclear envelope and endoplasmic reticulum (ER) []. LAP1 and LULL1 integrate into the Torsin ring to produce the biologically active ATPase machine []. Short Name:  Torsin-like
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0 Child Features

0 Contains

1 Cross References

Identifier
PTHR10760:SF2

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0005524 IPR030553
GO:0005635 IPR030553
GO:0005783 IPR030553

3 Ontology Annotations

GO Term Gene Name
GO:0005524 IPR030553
GO:0005635 IPR030553
GO:0005783 IPR030553

1 Parent Features

DB identifier Type Name
IPR017378 Family Torsin 1/2

2 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Cz04g24190.t1 PAC:38235628 Chromochloris zofingiensis 363  
Bobra.0044s0014.1.p PAC:40709542 Botryococcus braunii 340  

10 Publications

First Author Title Year Journal Volume Pages PubMed ID
            9927482
            25352667
            23569223
            15767459
            20861018
            22611399
            18550799
            11714689
            22022556
            16967506