Protein Domain : IPR001265

Type:  Family Name:  Formin homology family, Cappuccino subfamily
Description:  Formins (formin homology proteins) proteins play a crucial role in the reorganisation of the actin cytoskeleton and associate with the fast-growing end (barbed end) of actin filaments [, ]. This entry represents the formin homologues from animals (and some fungi), including protein cappuccino from Drosophila melanogaster and formins from human and mouse. Protein cappuccino acts as an actin nucleation factor and promotes assembly of actin filaments together with spir. It may play a role in intracellular vesicle transport along actin fibres, providing a novel link between actin cytoskeleton dynamics and intracellular transport []. Formins are characterised by the presence of three FH domains (FH1, FH2 and FH3), although members of the formin family do not necessarily contain all three domains []. The proline-rich FH1 domain mediates interactions with a variety of proteins, including the actin-binding protein profilin, SH3 (Src homology 3) domain proteins, and WW domain proteins. The FH2 domain is required for the self-association of formin proteins through the ability of FH2 domains to directly bind each other [], and may also act to inhibit actin polymerisation []. The FH3 domain () is less well conserved and may be important for determining intracellular localisation of formin family proteins. In addition, some formins can contain a GTPase-binding domain (GBD) () required for binding to Rho small GTPases, and a C-terminal conserved Dia-autoregulatory domain (DAD). Short Name:  Formin_Cappuccino_subfam
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0 Child Features

1 Contains

DB identifier Type Name
IPR015425 Domain Formin, FH2 domain

1 Cross References

Identifier
PR00828

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0008017 IPR001265
GO:0045010 IPR001265
GO:0005884 IPR001265

3 Ontology Annotations

GO Term Gene Name
GO:0008017 IPR001265
GO:0045010 IPR001265
GO:0005884 IPR001265

0 Parent Features

7 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
80558 C1E4B6 PAC:27400400 Micromonas sp RCC299 399  
Spipo5G0011500 PAC:31517804 Spirodela polyrhiza 436  
Aco012383.1 PAC:33051414 Ananas comosus 715  
Pavir.6NG169800.2.p PAC:37648359 Panicum virgatum 428  
Pavir.6NG169800.1.p PAC:37648358 Panicum virgatum 429  
HORVU6Hr1G085030.7 PAC:38505187 Hordeum vulgare 1024  
HORVU6Hr1G085030.3 PAC:38505186 Hordeum vulgare 1041  

6 Publications

First Author Title Year Journal Volume Pages PubMed ID
            10631086
            12538772
            14576350
            14992721
            12775772
            19633175