Protein Domain : IPR013158

Type:  Domain Name:  APOBEC-like, N-terminal
Description:  This domain is found at the N terminus of the Apolipoprotein B mRNA editing enzyme. Apobec-1 catalyzes C to U editing of apolipoprotein B (apoB) mRNA in the mammalian intestine. The N-terminal domain of APOBEC-1 like proteins is the catalytic domain, while the C-terminal domain is a pseudocatalyitc domain. More specifically, the catalytic domain is a zinc dependent deaminases domain and is essential for cytidine deamination. APOBEC-3 like members contain two copies of this domain. This family also includes the functionally homologous activation induced deaminase, which is essential for the development of antibody diversity in B lymphocytes. RNA editing by APOBEC-1 requires homodimerisation and this complex interacts with RNA binding proteins to from the editosome [] (and references therein). Short Name:  APOBEC_N
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0 Child Features

1 Contains

DB identifier Type Name
IPR016192 Binding_site APOBEC/CMP deaminase, zinc-binding

1 Cross References

Identifier
PF08210

1 Found In

DB identifier Type Name
IPR016193 Domain Cytidine deaminase-like

2 GO Annotations

GO Term Gene Name
GO:0008270 IPR013158
GO:0016814 IPR013158

2 Ontology Annotations

GO Term Gene Name
GO:0008270 IPR013158
GO:0016814 IPR013158

0 Parent Features

1 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
56782 C1E186 PAC:27398272 Micromonas sp RCC299 323  

1 Publications

First Author Title Year Journal Volume Pages PubMed ID
            12683974