Type: | Domain | Name: | Creatininase-like domain |
Description: | Creatinase () catalyses the hydrolysis of creatinine to creatine, which can then be metabolised to urea and sarcosine by creatinase. Formamide hydrolase catalyzes the hydrolysis of the formamide of 2-amino-5-formylamino-6-ribosylamino-4(3H)-pyrimidinone 5'-monophosphate (FAPy) to form 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (APy) ().Creatininase from Pseudomonas putida has a structure consisting of 3-layers, alpha/beta/alpha, where the core consists of a parallel beta-sheet of 4 strands. The enzyme is a typical Zn2+ enzyme with a binuclear metal centre [].This entry represents the structural domain found in creatininases and in formamide hydrolases. | Short Name: | Creatininase-like_dom |