Protein Domain : IPR013703

Type:  Domain Name:  Peptidase S49, N-terminal proteobacteria
Description:  Proteolytic enzymes that exploit serine in their catalytic activity are ubiquitous, being found in viruses, bacteria and eukaryotes []. They include a wide range of peptidase activity, including exopeptidase, endopeptidase, oligopeptidase and omega-peptidase activity. Many families of serine protease have been identified, these being grouped into clans on the basis of structural similarity and other functional evidence []. Structures are known for members of the clans and the structures indicate that some appear to be totally unrelated, suggesting different evolutionary origins for the serine peptidases [].Not withstanding their different evolutionary origins, there are similarities in the reaction mechanisms of several peptidases. Chymotrypsin, subtilisin and carboxypeptidase C have a catalytic triad of serine, aspartate and histidine in common: serine acts as a nucleophile, aspartate as an electrophile, and histidine as a base []. The geometric orientations of the catalytic residues are similar between families, despite different protein folds []. The linear arrangements of the catalytic residues commonly reflect clan relationships. For example the catalytic triad in the chymotrypsin clan (PA) is ordered HDS, but is ordered DHS in the subtilisin clan (SB) and SDH in the carboxypeptidase clan (SC) [, ].This domain is found to the N terminus of bacterial signal peptidases that belong to the MEROPS peptidase family S49 (protease IV family, clan SK) (see also ) [, ]. Short Name:  Peptidase_S49_N_proteobac
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0 Child Features

0 Contains

1 Cross References

Identifier
PF08496

0 Found In

2 GO Annotations

GO Term Gene Name
GO:0004252 IPR013703
GO:0005886 IPR013703

2 Ontology Annotations

GO Term Gene Name
GO:0004252 IPR013703
GO:0005886 IPR013703

0 Parent Features

4 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
55912 C1MNI5 PAC:27347273 Micromonas pusilla CCMP1545 848  
109506 C1EHG6 PAC:27403908 Micromonas sp RCC299 342  
33404 PAC:27413830 Ostreococcus lucimarinus 597  
Araha.11756s0022.1.p PAC:28856524 Arabidopsis halleri 327  

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            8439290
            7845208
            15611110
            15205439