Protein Domain : IPR005322

Type:  Family Name:  Peptidase C69, dipeptidase A
Description:  Cysteine peptidases have characteristic molecular topologies, which can be seen not only in their three-dimensional structures, but commonly also in the two-dimensional structures. These are peptidases in which the nucleophile is the sulphydryl group of a cysteine residue. Cysteine proteases are divided into clans (proteins which are evolutionary related), and further sub-divided into families, on the basis of the architecture of their catalytic dyad or triad []. This group of peptidases, belong to MEROPS peptidase family C69 (dipeptidase, clan PB). They are mainly dipeptidases [] and incude dipeptidase A from Lactobacillus helveticus. Comparative sequence and structural analysis, particularly to penicillin V acylase (MEROPS peptidase family C59) revealed a cysteine as the catalytic nucleophile as well as other conserved residues important for catalysis []. In general, C69 family is variable in sequence and exhibits great diversity in substrate specificity, to include enzymes such as choloyglycine hydrolases, acid ceramidases, isopenicillin N acyltransferases, and a subgroup of eukaryotic proteins with unclear function. Short Name:  Peptidase_C69
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0 Child Features

0 Contains

1 Cross References

Identifier
PF03577

0 Found In

2 GO Annotations

GO Term Gene Name
GO:0016805 IPR005322
GO:0006508 IPR005322

2 Ontology Annotations

GO Term Gene Name
GO:0016805 IPR005322
GO:0006508 IPR005322

0 Parent Features

4 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
54129 C1N8L0 PAC:27343602 Micromonas pusilla CCMP1545 651  
103294 C1FJW6 PAC:27399946 Micromonas sp RCC299 485  
81605 C1E7F2 PAC:27395924 Micromonas sp RCC299 608  
Pum0154s0002.1.p A0A1X6P8T1 PAC:38016001 Porphyra umbilicalis 738  

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            11517925
            8766699
            12717035