Protein Domain : IPR000607

Type:  Domain Name:  Double-stranded RNA-specific adenosine deaminase (DRADA)
Description:  Double-stranded RNA-specific adenosine deaminase () converts multiple adenosines to inosines and creates I/U mismatched base pairs in double-helical RNA substrates without apparent sequencespecificity. DRADA has been found to modify adenosines in AU-rich regions more frequently, probably due to the relative ease of melting A/U base pairs compared to G/C base pairs. The protein functions tomodify viral RNA genomes, and may be responsible for hypermutation of certain negative-stranded viruses. DRADA edits the mRNAs for the glutamate receptor subunits by site-selective adenosine deamination. TheDRADA repeat is also found in viral E3 proteins, which contain a double-stranded RNA-binding domain. Short Name:  dsRNA_A_deaminase
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0 Child Features

0 Contains

3 Cross Referencess

Identifier
PF02295
PS50139
SM00550

1 Found In

DB identifier Type Name
IPR009179 Family Interferon resistance/PKR inhibitor, vaccinia E3L type

2 GO Annotations

GO Term Gene Name
GO:0003723 IPR000607
GO:0003726 IPR000607

2 Ontology Annotations

GO Term Gene Name
GO:0003723 IPR000607
GO:0003726 IPR000607

1 Parent Features

DB identifier Type Name
IPR011991 Domain Winged helix-turn-helix DNA-binding domain

5 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
52426 C1N462 PAC:27349062 Micromonas pusilla CCMP1545 442  
103975 C1EGI3 PAC:27403912 Micromonas sp RCC299 411  
Mapoly0062s0008.1.p A0A2R6WRT6 PAC:33016725 Marchantia polymorpha 400  
Brdisv1BdTR10C1020563m.p PAC:35379976 Brachypodium distachyon BdTR10c 604  
Eusyr.0133s0161.1.p PAC:39700937 Euclidium syriacum 493  

0 Publications