Protein Domain : IPR019402

Type:  Family Name:  Frag1/DRAM/Sfk1
Description:  This entry includes Frag1, DRAM and Sfk1 proteins. Frag1 (FGF receptor activating protein 1) is a protein that is conserved from fungi to humans. There are four potential iso-prenylation sites throughout the peptide, CILW (x2), CIIW and CIGL. Frag1 is a membrane-spanning protein that is ubiquitously expressed in adult tissues suggesting an important cellular function []. DRAM is a family of proteins conserved from nematodes to humans with six hydrophobic transmembrane regions and an endoplasmic reticulum signal peptide. It is a lysosomal protein that induces macro-autophagy as an effector of p53-mediated death, where p53 is the tumour-suppressor gene that is frequently mutated in cancer. Expression of DRAM is stress-induced []. This region is also part of a family of small plasma membrane proteins, referred to as Sfk1, that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, thus allowing proper localisation of Stt4p to the actin cytoskeleton [, ]. Short Name:  Frag1/DRAM/Sfk1
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1 Child Features

DB identifier Type Name
IPR027315 Family Transmembrane protein 150A

0 Contains

1 Cross References

Identifier
PF10277

0 Found In

0 GO Annotation

0 Ontology Annotations

0 Parent Features

6 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
189219 C1N152 PAC:27340486 Micromonas pusilla CCMP1545 438  
103500 C1FJ03 PAC:27399494 Micromonas sp RCC299 393  
108083 C1E3U6 PAC:27400497 Micromonas sp RCC299 250  
30433 A4RTY8 PAC:27413201 Ostreococcus lucimarinus 242  
Pum0143s0013.1.p A0A1X6P9S9 PAC:38009349 Porphyra umbilicalis 291  
Cocit.L5335.1.p PAC:41063000 Corymbia citriodora 184  

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            10585768
            16839881
            12837385
            12015967