Protein Domain : IPR000175

Type:  Family Name:  Sodium:neurotransmitter symporter
Description:  Neurotransmitter transport systems are integral to the release, re-uptake and recycling of neurotransmitters at synapses. High affinity transport proteins found in the plasma membrane of presynaptic nerve terminals and glial cells are responsible for the removal from the extracellular space of released-transmitters, thereby terminating their actions []. Plasma membrane neurotransmitter transporters fall into two structurally and mechanistically distinct families. The majority of the transporters constitute an extensive family of homologous proteins that derive energy from the co-transport of Na+and Cl-, in order to transport neurotransmitter molecules into the cell against their concentration gradient. The family has a common structure of 12 presumed transmembrane helices and includes carriers for gamma-aminobutyric acid (GABA), noradrenaline/adrenaline, dopamine, serotonin, proline, glycine, choline, betaine and taurine. They are structurally distinct from the second more-restricted family of plasma membrane transporters, which are responsible for excitatory amino acid transport. The latter couple glutamate and aspartate uptake to the cotransport of Na+and the counter-transport of K+, with no apparent dependence on Cl-[]. In addition, both of these transporter families are distinct from the vesicular neurotransmitter transporters [, ].Sequence analysis of the Na+/Cl-neurotransmitter superfamily reveals that it can be divided into four subfamilies, these being transporters for monoamines, the amino acids proline and glycine, GABA, and a group of orphan transporters []. Short Name:  Na/ntran_symport
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11 Child Features

DB identifier Type Name
IPR002435 Family Sodium:neurotransmitter symporter, noradrenaline
IPR002434 Family Sodium:neurotransmitter symporter, taurine
IPR002436 Family Sodium:neurotransmitter symporter, dopamine
IPR002438 Family Sodium:neurotransmitter symporter, orphan
IPR003028 Family Sodium:neurotransmitter symporter, glycine, type 1
IPR002944 Family Sodium:neurotransmitter symporter, inebriated
IPR002980 Family Sodium:neurotransmitter symporter, GABA, GAT-1
IPR002981 Family Sodium:neurotransmitter symporter, GABA, GAT-2
IPR002982 Family Sodium:neurotransmitter symporter, GABA, GAT-3
IPR002983 Family Sodium:neurotransmitter symporter, betaine
IPR002984 Family Sodium:neurotransmitter symporter, creatine

0 Contains

6 Cross Referencess

Identifier
PTHR11616
PF00209
PR00176
PS00610
PS00754
PS50267

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0005328 IPR000175
GO:0006836 IPR000175
GO:0016021 IPR000175

3 Ontology Annotations

GO Term Gene Name
GO:0005328 IPR000175
GO:0006836 IPR000175
GO:0016021 IPR000175

0 Parent Features

9 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
148278 PAC:27345630 Micromonas pusilla CCMP1545 588  
77544 C1FF57 PAC:27398838 Micromonas sp RCC299 618  
Dusal.0645s00009.2.p PAC:33186264 Dunaliella salina 695  
Dusal.0645s00009.1.p PAC:33186263 Dunaliella salina 720  
Brdisv1pangenome1009942m.p PAC:33657980 Brachypodium distachyon Pangenome 641  
Brdisv1pangenome1013080m.p PAC:33658024 Brachypodium distachyon Pangenome 907  
Brdisv1BdTR11A1047624m.p PAC:35697180 Brachypodium distachyon BdTR11a 472  
Solyc12g063000.1.1 PAC:36147997 Solanum lycopersicum 1802  
Solyc12g062990.1.1 PAC:36148093 Solanum lycopersicum 912  

5 Publications

First Author Title Year Journal Volume Pages PubMed ID
            15336049
            8811182
            8103691
            7823024
            9779464