Protein Domain : IPR006000

Type:  Family Name:  Xylulokinase
Description:  The ability to metabolise xylose, one of the most abundant sugars in nature, is dependent on its conversion to xylulose-5-phosphate, which then enters the non-oxidative pentose phosphate pathway []. Xylulose-5-phosphate is produced from xylose by the sequential action of two enzymes; xylose isomerase, which converts xylose to xylulose, and xylulokinase, which subsequently phosphorylates xylulose.This entry represents bacterial xylulokinase. In addition to its role in xylose metabolism this enzyme may also have a biosynthetic role. 1-deoxy-D-xylulose 5-phosphate serves as a precursor for the biosynthesis of the vitamins thiamine and pyridoxal and for the formation of isopentenyl pyrophosphate and dimethylallyl pyrophosphate via the nonmevalonate pathway of terpenoid biosynthesis. Xylulokinase catalyses the phosphorylation of 1-deoxy-D-xylulose at the hydroxy group of C-5 []. This reaction therefore constitutes a potential salvage pathway for the generation of 1-deoxy-D-xylulose 5-phosphate from exogenous or endogenous 1-deoxy-D-xylulose as starting material for the biosynthesis of terpenoids, thiamine and pyridoxal. Short Name:  Xylulokinase
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0 Child Features

3 Contains

DB identifier Type Name
IPR018485 Domain Carbohydrate kinase, FGGY, C-terminal
IPR018484 Domain Carbohydrate kinase, FGGY, N-terminal
IPR018483 Conserved_site Carbohydrate kinase, FGGY, conserved site

1 Cross References

Identifier
TIGR01312

0 Found In

2 GO Annotations

GO Term Gene Name
GO:0004856 IPR006000
GO:0005997 IPR006000

2 Ontology Annotations

GO Term Gene Name
GO:0004856 IPR006000
GO:0005997 IPR006000

1 Parent Features

DB identifier Type Name
IPR000577 Family Carbohydrate kinase, FGGY

7 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
30441 I0YQU7 PAC:27387838 Coccomyxa subellipsoidea C-169 481  
168277 C1MP31 PAC:27347500 Micromonas pusilla CCMP1545 552  
67870 C1EGW7 PAC:27403915 Micromonas sp RCC299 434  
Cre07.g321100.t1.2 A0A2K3DJ20 PAC:30775427 Chlamydomonas reinhardtii 487  
Dusal.0724s00002.1.p PAC:33190223 Dunaliella salina 512  
Cz01g32300.t1 PAC:38237144 Chromochloris zofingiensis 481  
Vocar.0021s0156.1.p PAC:32895858 Volvox carteri 485  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            17123542
            11168365