1 Proteins
| DB identifier | UniProt Accession | Secondary Identifier | Organism Name | Length |
|---|---|---|---|---|
| 24411 | I0YTN2 | PAC:27392125 | Coccomyxa subellipsoidea C-169 |
278
 |
| Type: | Family | Name: | Isochorismatase |
| Description: | Iron is essential for growth in both bacteria and mammals. Controlling the amount of free iron in solution is often used as a tactic by hosts to limitinvasion of pathogenic microbes; binding iron tightly within protein molecules can accomplish this. Such iron-protein complexes include haem inblood, lactoferrin in tears/saliva and transferrin in blood plasma. Somebacteria express surface receptors to capture eukaryotic iron-binding compounds, while others have evolved siderophores to scavenge iron fromiron-binding host proteins [].The absence of free iron molecules in the surrounding environment triggers transcription of gene clusters that encode both siderophore-synthesis enzymes, and receptors that recognise iron-bound siderophores []. Classicexamples are the enterobactin/enterochelin clusters found in Escherichia coli and Salmonella spp., although similar moieties in other pathogens have been identified. The enzymic machinery that produces vibrionectin in Vibrio cholera is such a homologue [].EntB, an isochorismate enzyme, is involved in the second stage of enterobactin biosynthesis. It has a molecular weight of 35kDa, and is believed to possess bifunctional activity. Deletion studies involving EntB- mutants have shown that it is essential for virulence [].This group represents an isochorismatase. | Short Name: | Isochorismatase |
| DB identifier | UniProt Accession | Secondary Identifier | Organism Name | Length |
|---|---|---|---|---|
| 24411 | I0YTN2 | PAC:27392125 | Coccomyxa subellipsoidea C-169 |
278
|
