Protein Domain : IPR021569

Type:  Domain Name:  TUG ubiquitin-like domain
Description:  This entry represents the N-terminal ubiquitin-like domain of the TUG protein. This domain in the similar protein, UBL1, appears to participate in protein-protein interactions []. The region does have a area of negative electrostatic potential and increased backbone motility which leads to suggestions of a potential protein-protein interaction site []. This domain is also found at the N terminus of yeast Ubx4 [].Proteins containing this domain include Ubx4 from budding yeast and TUG (also known as tether containing UBX domain for GLUT4) from mice. Ubx4 is involved in Cdc48-dependent protein degradation through the ubiquitin/proteasome pathway []. TUG is a GLUT4 regulating protein and functions to retain membrane vesicles containing GLUT4 intracellularly. TUG releases the GLUT4 containing vesicles to the cellular exocytic machinery in response to insulin stimulation which allows translocation to the plasma membrane []. TUG has an N-terminal ubiquitin-like domain (UBL1) which in similar proteins appears to participate in protein-protein interactions []. The region does have a area of negative electrostatic potential and increased backbone motility which leads to suggestions of a potential protein-protein interaction site []. Short Name:  TUG-UBL1
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0 Child Features

0 Contains

1 Cross References

Identifier
PF11470

0 Found In

0 GO Annotation

0 Ontology Annotations

1 Parent Features

DB identifier Type Name
IPR029071 Domain Ubiquitin-related domain

7 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
45770 I0Z977 PAC:27388922 Coccomyxa subellipsoidea C-169 373  
Cre10.g443650.t1.1 A0A2K3DAN0 PAC:30789741 Chlamydomonas reinhardtii 505  
Dusal.0229s00004.1.p PAC:33187456 Dunaliella salina 629  
Cz05g35230.t1 PAC:38242527 Chromochloris zofingiensis 380  
Bobra.0172s0060.1.p PAC:40711521 Botryococcus braunii 412  
Bobra.0172s0060.3.p PAC:40711523 Botryococcus braunii 325  
Bobra.0172s0060.2.p PAC:40711522 Botryococcus braunii 384  

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            16501224
            19359248
            1935924