Protein Domain : IPR010080

Type:  Domain Name:  Thioester reductase-like domain
Description:  This domain includes the C-terminal domain from the fungal alpha aminoadipate reductase enzyme (also known as aminoadipate semialdehyde dehydrogenase) which is involved in the biosynthesis of lysine [], as well as the reductase-containing component of the myxochelin biosynthetic gene cluster, MxcG []. The mechanism of reduction involves activation of the substrate by adenylation and transfer to a covalently-linked pantetheine cofactor as a thioester. This thioester is then reduced to give an aldehyde (thus releasing the product) and a regenerated pantetheine thiol []; in myxochelin biosynthesis this aldehyde is further reduced to an alcohol or converted to an amine by an aminotransferase. This is a fundamentally different reaction than beta-ketoreductase domains of polyketide synthases which act at a carbonyl two carbons removed from the thioester and forms an alcohol as a product. The majority of bacterial sequences containing this domain are non-ribosomal peptide synthetases in which this domain is similarly located proximal to a thiolation domain. In some cases this domain is found at the end of a polyketide synthetase enzyme, but is unlike ketoreductase domains which are found before the thiolase domains. Exceptions to this observed relationship with the thiolase domain include three proteins which consist of stand-alone reductase domains (from Mycobacterium leprae, Anabaena and from Streptomyces coelicolor) and one protein (from Nostoc) which contains N-terminal homology with a small group of hypothetical proteins but no evidence of a thiolation domain next to the putative reductase domain. Short Name:  Thioester_reductase-like_dom
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0 Child Features

0 Contains

1 Cross References

Identifier
TIGR01746

1 Found In

DB identifier Type Name
IPR014397 Family L-aminoadipate-semialdehyde dehydrogenase

0 GO Annotation

0 Ontology Annotations

1 Parent Features

DB identifier Type Name
IPR013120 Domain Male sterility, NAD-binding

3 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
48249 I0YRM5 PAC:27386171 Coccomyxa subellipsoidea C-169 1465  
45744 I0Z921 PAC:27388918 Coccomyxa subellipsoidea C-169 1193  
Mapoly0066s0079.1.p A0A2R6WQK6 PAC:33005950 Marchantia polymorpha 1028  

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            11254122
            11029592
            10320345