3 Ontology Annotations
| GO Term | Gene Name |
|---|---|
| GO:0045132 | IPR011515 |
| GO:0000775 | IPR011515 |
| GO:0005634 | IPR011515 |
| Type: | Domain | Name: | Shugoshin, C-terminal |
| Description: | This entry represents the C-terminal domain of Shugoshin (Sgo1) kinetochore-attachment proteins. Shugoshin has a conserved coiled-coil N-terminal domain and a highly conserved C-terminal basic region (). Shugoshin is a crucial target of Bub1 kinase that plays a central role in chromosome cohesion during mitosis and meiosis divisions by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms [, ]. Shugoshin is thought to act by protecting Rec8 and Rad21 at the centromeres from separase degradation during anaphase I (during meiosis) so that sister chromatids remain tethered []. Shugoshin also acts as a spindle checkpoint component required for sensing tension between sister chromatids during mitosis, its degradation when they separate preventing cell cycle arrest and chromosome loss in anaphase, a time when sister chromatids are no longer under tension. Human shugoshin is diffusible and mediates kinetochore-driven formation of kinetochore-microtubules during bipolar spindle assembly []. Further, the primary role of shugoshin is to ensure bipolar attachment of kinetochores, and its role in protecting cohesion has co-developed to facilitate this process []. | Short Name: | Shugoshin_C |
| GO Term | Gene Name |
|---|---|
| GO:0045132 | IPR011515 |
| GO:0000775 | IPR011515 |
| GO:0005634 | IPR011515 |
