| Type: | Domain | Name: | Fibronectin, type II, collagen-binding |
| Description: | Fibronectin is a multi-domain glycoprotein, found in a soluble form in plasma, and in an insoluble form in loose connective tissue and basement membranes, that binds cell surfaces and various compounds including collagen,fibrin, heparin, DNA, and actin. Fibronectins are involved in a number of important functions e.g., wound healing; cell adhesion; blood coagulation; cell differentiation and migration; maintenance of the cellularcytoskeleton; and tumour metastasis []. The major part of the sequence of fibronectin consists of therepetition of three types of domains, which are called type I, II, and III []. Type II domain isapproximately forty residues long, contains four conserved cysteines involved in disulphide bonds and is part of the collagen-binding region of fibronectin. In fibronectin the type II domain is duplicated. Type II domains havealso been found in a range of proteins including blood coagulation factor XII; bovine seminal plasma proteins PDC-109 (BSP-A1/A2) and BSP-A3 []; cation-independent mannose-6-phosphate receptor [];mannose receptor of macrophages []; 180 Kd secretory phospholipase A2 receptor []. DEC-205receptor []; 72 Kd and 92 Kd type IV collagenase () []; and hepatocytegrowth factor activator []. | Short Name: | FN_type2_col-bd |
