| Type: | Domain | Name: | GTP-binding protein TrmE/Glycine cleavage system T protein, domain 1 |
| Description: | This entry represents an alpha/beta domain found in GTP-binding protein TrmE (N-terminal domain) [] and in glycine cleavage T-protein (domain 1) [].TrmE is a guanine nucleotide-binding protein conserved between bacteria and eukaryotes. It is involved in the modification of uridine bases at the first anticodon (wobble) position of tRNAs. The N-terminal portion of the protein is necessary for mediating dimer formation within the protein []. Glycine cleavage T-protein is part of the glycine cleavage multienzyme complex (GCV) found in bacteria and the mitochondria of eukaryotes []. GCV catalyses the oxidative decarboxylation of glycine. The T-protein is an aminomethyl transferase . The N-terminal region (residues 14-35) of domain 1 plays a crucial role in H-protein interaction []. | Short Name: | TrmE/GcvT_dom1 |
