| Type: | Domain | Name: | Sushi/SCR/CCP domain |
| Description: | The extracellular sushi domain is characterised by a consensus sequence spanning ~60 residues containing four invariant cysteine residues forming twodisulfide-bridges (I-III and II-IV), a highly conserved tryptophan, and conserved glycine, proline, and hydrophobic residues []. Sushi domains areknown to be involved in many recognition processes, including the binding of several complement factors to fragments C3b and C4b []. The sushi domain isalso known as the complement controle protein (CCP) module or the short consensus repeat (SCR). Several structure of the sushi domain have been solved (see for example {PDB:1HCC}) []. The sushi domain folds into a small and compact hydrophobiccore enveloped by six beta-strands and stabilised by two disulfide bridges. The relative structural orientation of the Beta-2 and Beta-4 strands is sharedby all the sushi structures, whereas the topology of the other strands relative to this central conserved core is variable, especially at the regionsthat form the interfaces with the preceding and following domains []. | Short Name: | Sushi_SCR_CCP_dom |
