Protein Domain : IPR000859

Type:  Domain Name:  CUB domain
Description:  The CUB domain (for complement C1r/C1s, Uegf, Bmp1) is a structural motif of approximately 110 residues found almost exclusively in extracellular and plasma membrane-associated proteins, many of which are developmentally regulated [, ]. These proteins are involved in a diverse range of functions, including complement activation, developmental patterning, tissue repair, axon guidance and angiogenesis, cell signalling, fertilisation, haemostasis, inflammation, neurotransmission, receptor-mediated endocytosis, and tumour suppression []. Many CUB-containing proteins are peptidases belonging to MEROPS peptidase families M12A (astacin) and S1A (chymotrypsin). Proteins containing a CUB domain include:Mammalian complement subcomponents C1s/C1r, which form the calcium-dependent complex C1, the first component of the classical pathway of the complement system.Cricetidae sp.(Hamster) serine protease Casp, which degrades type I and IV collagen and fibronectin in the presence of calcium.Mammalian complement-activating component of Ra-reactive factor (RARF), a protease that cleaves the C4 component of complement.Vertebrate enteropeptidase (), a type II membrane protein of the intestinal brush border, which activates trypsinogen.Vertebrate bone morphogenic protein 1 (BMP-1), a protein which induces cartilage and bone formation and expresses metalloendopeptidase activity.Sea urchin blastula proteins BP10 and SpAN.Caenorhabditis eleganshypothetical proteins F42A10.8 and R151.5.Neuropilin (A5 antigen), a calcium-independent cell adhesion molecule that functions during the formation of certain neuronal circuits.Fibropellins I and III from Strongylocentrotus purpuratus(Purple sea urchin).Mammalian hyaluronate-binding protein TSG-6 (or PS4), a serum and growth factor induced protein.Mammalian spermadhesins.Xenopus laevisembryonic protein UVS.2, which is expressed during dorsoanterior development.Several of the above proteins consist of a catalytic domain together with several CUB domains interspersed by calcium-binding EGF domains. Some CUB domains appear to be involved in oligomerisation and/or recognition of substrates and binding partners. For example, in the complement proteases, the CUB domains mediate dimerisation and binding to collagen-like regions of target proteins (e.g. C1q for C1r/C1s). The structure of CUB domains consists of a beta-sandwich with a jelly-roll fold. Almost all CUB domains contain four conserved cysteines that probably form two disulphide bridges (C1-C2, C3-C4). The CUB1 domains of C1s and Map19 have calcium-binding sites []. Short Name:  CUB_dom
Paste the following link

0 Child Features

0 Contains

5 Cross Referencess

Identifier
PF00431
PS01180
SM00042
G3DSA:2.60.120.290
SSF49854

11 Found Ins

DB identifier Type Name
IPR017118 Family Peptidase S1A, matriptase-2
IPR011163 Family Peptidase S1A, enteropeptidase
IPR017051 Family Peptidase S1A, matripase
IPR016857 Family Uncharacterised conserved protein UCP027682, CUB, vWA
IPR000124 Family Spermadhesin
IPR015446 Family Bone morphogenetic protein 1/tolloid-like protein
IPR014648 Family Neuropilin
IPR017076 Family Kremen
IPR017369 Family SPAN protein/blastula protease 10
IPR017050 Family Metallopeptidase, nematode
IPR017370 Family Hatching enzyme, Uvs2

0 GO Annotation

0 Ontology Annotations

0 Parent Features

327 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
evm.model.supercontig_252.1 PAC:16414930 Carica papaya 561  
evm.model.supercontig_43.81 PAC:16420043 Carica papaya 113  
Cucsa.135710.1 A0A0A0KD23 PAC:16962979 Cucumis sativus 470  
AT5G59700.1 Q9FN92 PAC:19672792 Arabidopsis thaliana 829  
Lus10030172 PAC:23153146 Linum usitatissimum 321  
Lus10033906 PAC:23172799 Linum usitatissimum 99  
Lus10038487 PAC:23158181 Linum usitatissimum 454  
Potri.015G135900.1 A0A2K1XMJ7 PAC:27018506 Populus trichocarpa 102  
Potri.012G133700.1 B9I4F9 PAC:27050038 Populus trichocarpa 154  
Potri.002G129000.1 PAC:27022467 Populus trichocarpa 1249  
Potri.002G129000.2 PAC:27022468 Populus trichocarpa 987  
43400 I0YRM0 PAC:27386338 Coccomyxa subellipsoidea C-169 557  
39393 C1MQS3 PAC:27346528 Micromonas pusilla CCMP1545 2070  
Araha.40074s0003.1.p PAC:28850248 Arabidopsis halleri 876  
Cagra.1317s0047.1.p PAC:28910436 Capsella grandiflora 832  
Bostr.0568s0550.2.p PAC:30669606 Boechera stricta 476  
Cre02.g094600.t1.1 A0A2K3E1H0 PAC:30786085 Chlamydomonas reinhardtii 2627  
Cre05.g241640.t2.1 A0A2K3DSK0 PAC:30783001 Chlamydomonas reinhardtii 1118  
Cre05.g241640.t1.1 A0A2K3DSK0 PAC:30783000 Chlamydomonas reinhardtii 1118  
Medtr5g094650.1 G7K4F7 PAC:31088766 Medicago truncatula 67  
Medtr7g081640.1 G7KTG4 PAC:31082050 Medicago truncatula 65  
SapurV1A.0400s0200.1.p PAC:31441353 Salix purpurea 154  
SapurV1A.0101s0100.1.p PAC:31448057 Salix purpurea 330  
SapurV1A.0497s0080.5.p PAC:31410237 Salix purpurea 131  
SapurV1A.0497s0080.7.p PAC:31410235 Salix purpurea 131  
SapurV1A.0497s0080.6.p PAC:31410236 Salix purpurea 131  
SapurV1A.0497s0080.4.p PAC:31410234 Salix purpurea 184  
SapurV1A.0152s0040.5.p PAC:31415029 Salix purpurea 356  
evm_27.model.AmTr_v1.0_scaffold00116.4 W1NQM3 PAC:31575850 Amborella trichopoda 472  
Eucgr.H01605.1.p A0A059AZY8 PAC:32041358 Eucalyptus grandis 1006  

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            8510165
            2026272
            17446170
            17335815